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Stem Cells

Tracheal remodelling supports stem cells

Nature Cell Biology volume 23, pages 580–582 (2021)Cite this article

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The vascular system, plastic and positioned in the vicinity of tissues, is an undervalued regulator of adult stem cells. Two studies now show that the vascular-like Drosophila trachea is reshaped after intestinal damage or tumour formation and that this remodelling is required for compensatory intestinal stem cell proliferation and tumour growth.

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Fig. 1: Schematic of the dialogue between the intestinal epithelium and the tracheal system in homeostasis, infection, cancer and hypoxia.

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Authors and Affiliations

  1. Institut Curie, PSL Research University, CNRS UMR 3215, INSERM U934, Stem Cells and Tissue Homeostasis Group, Paris, France

    Louis Gervais & Allison J. Bardin

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  1. Louis Gervais
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  2. Allison J. Bardin
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Correspondence to Louis Gervais or Allison J. Bardin.

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The authors declare no competing interests.

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Gervais, L., Bardin, A.J. Tracheal remodelling supports stem cells. Nat Cell Biol 23, 580–582 (2021). https://doi.org/10.1038/s41556-021-00695-w

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