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Crystal Structure and Physicochemical Characteristics of Two Novel Adamantane Derivatives of Sulfonamides

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Abstract

Two derivatives of adamantane benzenesulfamide have been synthesized and studied: N-adamantane-1-yl-2,4,6-trimethyl-benzenesulfamide (1) and N-adamantane-1-yl-4-methoxy-benzenesulfamide (2). Crystal structures 1 and 2 are solved using X-ray diffraction (XRD) analysis. The solubilities of compounds in a phosphate buffer solution with pH 7.4, 1-octanol, and n-hexane are determined at several temperature points using isothermal saturation. The values of Gibbs energy, enthalpy, and entropy of solubility of the compounds at 298 K are determined.

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Funding

This study was supported by the Ministry of Science and Higher Education of the Russian Federation (project no. 075-03-2020-223 (FSSF-2020-0017)) and within the State assignment (state registration no. 0089-2019-0011).

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Authors and Affiliations

  1. Peoples’ Friendship University of Russia (RUDN University), 117198, Moscow, Russia

    O. V. Kovalchukova

  2. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    V. P. Kazachenko, V. V. Tkachev, N. N. Strakhova & A. N. Proshin

  3. Institute of Problems of Chemical Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    V. V. Tkachev & A. N. Utenyshev

  4. Sechenov First Moscow State Medical University (Sechenov University), 119991, Moscow, Russia

    A. N. Utenyshev

Authors
  1. O. V. Kovalchukova
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  2. V. P. Kazachenko
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  3. V. V. Tkachev
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  4. A. N. Utenyshev
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  5. N. N. Strakhova
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  6. A. N. Proshin
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Corresponding author

Correspondence to O. V. Kovalchukova.

Additional information

Translated by Yu. Sin’kov

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Kovalchukova, O.V., Kazachenko, V.P., Tkachev, V.V. et al. Crystal Structure and Physicochemical Characteristics of Two Novel Adamantane Derivatives of Sulfonamides. Crystallogr. Rep. 66, 424–428 (2021). https://doi.org/10.1134/S1063774521030123

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  • DOI: https://doi.org/10.1134/S1063774521030123

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