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Two new dipimprinine alkaloids from soil-derived Streptomyces sp. 44414B

The Journal of Antibiotics volume 74, pages 474–476 (2021)Cite this article

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Abstract

Two new dipimprinine alkaloids dipimprinine E (1) and dipimprinine F (2) were isolated from Streptomyces sp. 44414B. The structure was elucidated by extensive spectroscopic analysis, including ESI-MS, HR-MS, and 1D and 2D NMR experiments. Dipimprinines F (2) showed cytotoxic activities against three tumor cell lines, including A-875, Hep G2, and H-460, with IC50 values of 26.4, 0.5, and 9.0 μg ml−1, respectively.

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Acknowledgements

This research was financially supported by Special fund projects of central government guiding local science and technology development (2019ZYYD061) and Hubei agricultural science and technology innovation center (2019-620-000-001-027).

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Authors and Affiliations

  1. Hubei Biopesticide Engineering Research Centre, Hubei Academy of Agricultural Sciences, Wuhan, China

    Manli Liu, Zhongyi Wan, Fang Liu, Zhaoyuan Wu, Yanni Zhang, Kaimei Wang & Wei Fang

  2. Department of Pharmacy, Medical College, Wuhan University of Science and Technology, Wuhan, China

    Sumei Yang & Xiliang Yang

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  1. Manli Liu
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Correspondence to Wei Fang.

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Liu, M., Wan, Z., Yang, S. et al. Two new dipimprinine alkaloids from soil-derived Streptomyces sp. 44414B. J Antibiot 74, 474–476 (2021). https://doi.org/10.1038/s41429-021-00424-3

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