Transcriptome landscape of double negative T cells by single-cell RNA sequencing
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Keywords
Double negative T cell
Single-cell RNA sequencing
Unconventional T cells
Inflammation
Regulatory T cells
Innate immunity
Abbreviations
αGalCer
α-Galactosylceramide
aDNT
activated double-negative T cell
CD4
CD4+ T cell
CD8
CD8+ T cell
DNT
double-negative T cell
DGE
digital gene expression
DEG
differentially expressed genes
FACS
fluorescence activated cell sorting
GO
gene ontology
HEGs
highly expressed genes
LPC
lysophospholipid
MAIT
mucosal-associated invariant T cell
nDNT
naïve double-negative T cell
NK
natural killer cell
NKT
natural killer T cell
qRT-PCR
quantitative reverse transcriptase PCR
scRNA-seq
single-cell RNA sequencing
Treg
regulatory T cell
UMAP
uniform manifold approximation and projection
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Lu Yang, Yanbing Zhu, Dan Tian and Song Wang contributed equally to this work.
© 2021 The Authors. Published by Elsevier Ltd.