Abstract
Nitrones have been found to exhibit attractive biological values as immuno spin trapping agents. However, successful clinical cases of nitrone therapeutics are still lacking. Herein we report the synthesis and antiproliferative activity of a series of structurally diverse nitrone derivatives against a panel of 5 cancer cell lines, based on which indole- and pyrrole-fused were further evaluated by analogue preparation and in-vitro screening. Analogues with moderate to good potency were identified. This study shows the promise for further pursuit of nitrone-type small molecules in chemotherapy.
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We are grateful to National Natural Science Foundation of China (21871045), the natural science foundation of Jilin Province (20190201070JC) and Changchun University of Technology for generous financial support.
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Zhou, W., Ju, D., Ao, Y. et al. Synthesis and evaluation of cyclic nitrone derivatives as potential anti-cancer agents. Med Chem Res 30, 1309–1316 (2021). https://doi.org/10.1007/s00044-021-02729-2
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DOI: https://doi.org/10.1007/s00044-021-02729-2