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TUMOR IMMUNOLOGY

Enhancing anti-tumor immunity by autophagy inhibition

Nature Cancer volume 2, pages 484–486 (2021)Cite this article

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Two recent studies demonstrate how autophagy, in both tumor cells and host tissues, regulates anti-tumor T cell responses. These works add to accumulating evidence that inhibitors of autophagy could be used in combination with immunotherapy in certain cancer types.

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Fig. 1: Systemic inhibition of autophagy can target multiple autophagy-mediated immunosuppressive mechanisms.

References

  1. Dikic, I. & Elazar, Z. Nat. Rev. Mol. Cell Biol. 19, 349–364 (2018).

    Article  CAS  Google Scholar 

  2. Mulcahy-Levy, J. M. & Thorburn, A. Cell Death Differ. 27, 843–857 (2020).

    Article  Google Scholar 

  3. Deng, J. et al. Nat. Cancer https://doi.org/10.1038/s43018-021-00208-6 (2021).

  4. Litchfield, K. et al. Cell 184, 596–614.e514 (2021).

    Article  CAS  Google Scholar 

  5. Bhatt, V. et al. Genes Dev. 33, 150–165 (2019).

    Article  CAS  Google Scholar 

  6. Poillet-Perez, L. et al. Nat. Can. 1, 923–934 (2020).

    Article  Google Scholar 

  7. Yamazaki, T. et al. Nat. Immunol. 21, 1160–1171 (2020).

    Article  CAS  Google Scholar 

  8. Yamamoto, K. et al. Nature 581, 100–105 (2020).

    Article  CAS  Google Scholar 

  9. Noman, M. Z. et al. Sci. Adv. 6, eaax7881 (2020).

    Article  CAS  Google Scholar 

  10. Sharma, G. et al. JCI Insight 5, e133225 (2020).

    Article  Google Scholar 

  11. DeVorkin, L. et al. Cell Rep. 27, 502–513.e505 (2019).

    Article  CAS  Google Scholar 

  12. Cunha, L. D. et al. Cell 175, 429–441.e416 (2018).

    Article  CAS  Google Scholar 

  13. Ma, X.-H. et al. J. Clin. Invest. 124, 1406–1417 (2014).

    Article  CAS  Google Scholar 

  14. Mulcahy Levy, J. M. et al. eLife 6, e19671 (2017).

    Article  Google Scholar 

  15. Kinsey, C. G. et al. Nat. Med. 25, 620–627 (2019).

    Article  CAS  Google Scholar 

Download references

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Author notes

  1. Christina G. Towers

    Present address: Molecular and Cell Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA

Authors and Affiliations

  1. Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA

    Andrew Thorburn & Christina G. Towers

Authors
  1. Andrew Thorburn
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  2. Christina G. Towers
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Correspondence to Andrew Thorburn or Christina G. Towers.

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The authors declare no competing interests.

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Thorburn, A., Towers, C.G. Enhancing anti-tumor immunity by autophagy inhibition. Nat Cancer 2, 484–486 (2021). https://doi.org/10.1038/s43018-021-00214-8

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