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Spectroscopic Analysis of the Interaction Between the Antiparasitic Drug Nitazoxanide and Bovine Serum Albumin

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Abstract

Nitazoxanide is one broad-spectrum antiparasitic drug, and its potential uses in clinic have attracted much attention in the past decades. The interaction of nitazoxanide with bovine serum albumin (BSA) was investigated systematically by fluorescence spectroscopy, UV–Vis absorption spectroscopy, CD spectroscopy and molecular docking study. The results indicated that the fluorescence quenching of BSA by nitazoxanide was static. The corresponding thermodynamic parameters ΔH, ΔS and ΔG calculated according to van’t Hoff equation revealed that both hydrophobic interaction and electrostatic interaction play great roles in the binding of nitazoxanide to BSA process CD spectroscopy which showed that the secondary structure of BSA is changed by nitazoxanide. Molecular docking study further indicated the strong binding affinity between nitazoxanide and BSA.

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Acknowledgments

We gratefully acknowledge the financial supports of the Foundation of Hubei Educational Committee (No. D20172904).

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Authors and Affiliations

  1. Hubei Key Laboratory for Processing and Application of Catalytic Materials, Huanggang, 438000, People’s Republic of China

    Z. M. Zhu & W. J. Zhang

  2. Computer School of Huanggang Normal University, Huanggang, 438000, People’s Republic of China

    Z. M. Zhu

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  1. Z. M. Zhu
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  2. W. J. Zhang
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Correspondence to W. J. Zhang.

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The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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Zhu, Z.M., Zhang, W.J. Spectroscopic Analysis of the Interaction Between the Antiparasitic Drug Nitazoxanide and Bovine Serum Albumin. Iran J Sci Technol Trans Sci 45, 867–873 (2021). https://doi.org/10.1007/s40995-021-01102-7

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  • DOI: https://doi.org/10.1007/s40995-021-01102-7

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