* Corresponding authors

^a Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
E-mail: hsuga@chem.s.u-tokyo.ac.jp

^b Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen 2100, Denmark

^c Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 3200008, Israel
E-mail: abrik@technion.ac.il

^d Department of Chemistry and Biochemistry, Center for Biomolecular Structure and Organization, University of Maryland, College Park, MD 20742, USA

^e The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa 31096, Israel