Abstract
Osteoporosis is very common in middle-aged and elderly people, and its main feature is a disease characterized by bone mass reduction and bone microstructure changes, accompanied by a corresponding increase in the risk of fracture. This is a disease affected by many factors and is more common in postmenopausal women. Currently, the treatment of osteoporosis is mainly to prevent bone resorption and reduce the risk of fracture; a variety of drugs have been used in the treatment of osteoporosis and achieved good results. In recent years, with the in-depth study of intestinal microorganisms, a strong impact of intestinal microflora on bone metabolism in terms of immunity has been reported. It can be observed in mouse-based models, which indicates that intestinal flora may be a potential new target for changing bone mineral density (BMD). Therefore, the intestinal flora is a complex system that affects and regulates the absorption of calcium and vitamin D. It affects the permeability of the intestine through its own secretion of related influencing factors and its own activities, and further affects the secretion of human hormones and immune response. Besides that, T helper cells, lymphocytes, TNF, IL-17, and the RANKL system play a key role. The impact of probiotics and prebiotics on humans is controversial due to the scarcity of research data. However, many studies have shown that the role of probiotics in different animals varies with gender, age and hormone secretion. Changes in the intestinal flora are closely related to osteopenia and/or osteoporosis. Changing its composition and activity may be a reliable strategy for altering bone quality, although further clinical studies are needed to determine the correct human method.
Keywords: Probiotics, prebiotics, Osteoporosis, bone mineral density, RANKL, Immune system.
Current Medicinal Chemistry
Title:The Role of Probiotics and Prebiotics in Osteolastogenesis and Immune Relevance
Volume: 28 Issue: 25
Author(s): Datong Li, Yuan Liu, Xiaobin Yang and Lingbo Kong*
Affiliation:
- Department of Spine, Honghui-hospital, Xi’an Jiaotong University, School of Medicine, Xi’an,China
Keywords: Probiotics, prebiotics, Osteoporosis, bone mineral density, RANKL, Immune system.
Abstract: Osteoporosis is very common in middle-aged and elderly people, and its main feature is a disease characterized by bone mass reduction and bone microstructure changes, accompanied by a corresponding increase in the risk of fracture. This is a disease affected by many factors and is more common in postmenopausal women. Currently, the treatment of osteoporosis is mainly to prevent bone resorption and reduce the risk of fracture; a variety of drugs have been used in the treatment of osteoporosis and achieved good results. In recent years, with the in-depth study of intestinal microorganisms, a strong impact of intestinal microflora on bone metabolism in terms of immunity has been reported. It can be observed in mouse-based models, which indicates that intestinal flora may be a potential new target for changing bone mineral density (BMD). Therefore, the intestinal flora is a complex system that affects and regulates the absorption of calcium and vitamin D. It affects the permeability of the intestine through its own secretion of related influencing factors and its own activities, and further affects the secretion of human hormones and immune response. Besides that, T helper cells, lymphocytes, TNF, IL-17, and the RANKL system play a key role. The impact of probiotics and prebiotics on humans is controversial due to the scarcity of research data. However, many studies have shown that the role of probiotics in different animals varies with gender, age and hormone secretion. Changes in the intestinal flora are closely related to osteopenia and/or osteoporosis. Changing its composition and activity may be a reliable strategy for altering bone quality, although further clinical studies are needed to determine the correct human method.
Export Options
About this article
Cite this article as:
Li Datong, Liu Yuan , Yang Xiaobin and Kong Lingbo *, The Role of Probiotics and Prebiotics in Osteolastogenesis and Immune Relevance, Current Medicinal Chemistry 2021; 28 (25) . https://dx.doi.org/10.2174/0929867328666210316115126
DOI https://dx.doi.org/10.2174/0929867328666210316115126 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Dimerization and Ion Binding Properties of S100P Protein
Protein & Peptide Letters Dietary Polyphenols and Type 2 Diabetes: Current Insights and Future Perspectives
Current Medicinal Chemistry Therapeutic Opportunities for Trophic Factors in Brain Inflammation
Current Pharmaceutical Analysis Editorial (Thematic Issue: Linkage of Neurodegenerative Disorders with Other Health Issues – Volume I)
CNS & Neurological Disorders - Drug Targets Pharmacologic Therapy for Cardiovascular Risk Reduction in Patients with the Metabolic Syndrome
Current Pharmaceutical Design Oxidative Stress and Skeletal Muscle Dysfunction with Aging
Current Aging Science Functional Genomics of Brain Aging and Alzheimers Disease: Focus on Selective Neuronal Vulnerability
Current Genomics Glycoxidation and Wound Healing in Diabetes: An Interesting Relationship
Current Diabetes Reviews Gestational Diabetes Mellitus Pharmacological Prevention and Treatment
Current Pharmaceutical Design Protein Aggregation and Self Assembly in Health and Disease
Current Proteomics Editorial (Thematic Issue: Endothelium: A Target for Therapeutic Intervention)
Current Vascular Pharmacology Updates on Aldose Reductase Inhibitors for Management of Diabetic Complications and Non-diabetic Diseases
Mini-Reviews in Medicinal Chemistry Matrix Metalloproteinases and their Tissue Inhibitors in Diabetes, Atherosclerosis and Prediction of the Cardiovascular Risk
Current Enzyme Inhibition Prevention of Vascular Complications in Diabetes Mellitus Patients: Focus on the Arterial Wall
Current Vascular Pharmacology Mitochondrial Permeability Transition Pore as a Suitable Targ e t for Neuroprotective Agents Against Alzheimer’s Disease
CNS & Neurological Disorders - Drug Targets Editorial [Hot Topic: Amyloid-Associated Disease Mechanisms in Alzheimers Disease (Guest Editor: Jeroen J.M. Hoozemans)]
Current Drug Targets - CNS & Neurological Disorders Phenotypic Screening Strategies for Neurodegenerative Diseases: A Pathway to Discover Novel Drug Candidates and Potential Disease Targets or Mechanisms
CNS & Neurological Disorders - Drug Targets Neuroprotection for Amyotrophic Lateral Sclerosis: Role of Stem Cells, Growth Factors, and Gene Therapy
Central Nervous System Agents in Medicinal Chemistry Diabetic Cardiomyopathy: Clinical and Metabolic Approach
Current Vascular Pharmacology Ladostigil: A Novel Multimodal Neuroprotective Drug with Cholinesterase and Brain-Selective Monoamine Oxidase Inhibitory Activities for Alzheimers Disease Treatment
Current Drug Targets