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Dopamine β-hydroxylase: An Essential and Optimal Immunohistochemical Marker for Pheochromocytoma and Sympathetic Paraganglioma

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References

  1. Kimura N, Capella C, DeLelis RA, Epstein J, Gill A, Kawashima A, et al. (2017) Extra-adrenal paragangliomas In Lloyd RV, Osamura RY, Kloppel G, Rosai J (ed) WHO Classification of Tumors of Endocrine Organs, 4th edn. IARC Press, Lyons, pp190-195.

    Google Scholar 

  2. Kimura N, Shiga K, Kaneko K, Sgisawa C, Katabami T, Naruse M (2020) The Diagnostic Dilemma of GATA3 Immunohistochemistry in Pheochromocytoma and Paraganglioma. Endocr Pathol 31:95-100.

    Article  CAS  Google Scholar 

  3. Miettinen M1, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, et al. (2014). GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors. Am J Surg Pathol 38: 13-22.

    Article  Google Scholar 

  4. Nagatsu T, Levitt M, Udenfriend S (1964) Tyrosine hydroxylase. The initial step in norepinephrine biosynthesis. J Biol Chem 239:2910–2917.

    Article  CAS  Google Scholar 

  5. Berends AMA, Eisenhofer G, Fishbein L, van der Horst-Schrivers ANA, Kema IP et al. (2019) Intricacies of the Molecular Machinery of Catecholamine Biosynthesis and Secretion by Chromaffin Cells of the Normal Adrenal Medulla and in Pheochromocytoma and Paraganglioma. Cancers (Basel) 11:1121-1154.

    Article  CAS  Google Scholar 

  6. Grouzmann E, Tschopp O, Triponez F, Matter M, Bilz S, Brandle M et al. (2015) Catecholamine metabolism in paraganglioma and pheochromocytoma: similar tumors in different sites? PLoS One 10(5): e0125426.

    Article  Google Scholar 

  7. Isobe, K.; Nakai, T.; Yukimasa, N.; Nanmoku, T.; Takekoshi, K.; Nomura, F (1998) Expression of mRNA coding for four catecholamine synthesizing enzymes in human adrenal pheochromocytomas. Eur J Endocrinol. 138:383–387.

    Article  CAS  Google Scholar 

  8. Kimura N, Miura Y, Nagatsu I, Nagura H (1992) Catecholamine synthesizing enzymes in 70 cases of functioning and non-functioning phaeochromocytoma and extra-adrenal paraganglioma. Virchows Arch A Pathol Anat Histopathol 421: 25–32.

    Article  CAS  Google Scholar 

  9. Kimura N (2017) Update on tumors of adrenal medulla and extra-adrenal paraganglia. AJSP: Reviews & Reports 22: 240–245.

  10. Timmers HJ, Pacak K, Huynh TT, Abu-Asab M, Tsokos M, Merino MJ et al. (2008) Biochemically silent abdominal paragangliomas in patients with mutations in the succinate dehydrogenase subunit B gene. J Clin Endocrinol Metab. 93:4826-32.

  11. Kimura N, Takekoshi K, Horii A, Morimoto R, Imai T, Oki Y et al. (2014) Clinicopathological study of SDHB mutation-related pheochromocytoma and sympathetic paraganglioma. Endocr Related Cancer 21: L13-6.

    Article  CAS  Google Scholar 

  12. Kimura N, Takekoshi K, Naruse M (2018) Risk stratification on pheochromocytoma and paraganglioma from laboratory and clinical medicine. J Clin Med. 7:241-252.

    Article  Google Scholar 

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Funding

This study was conducted as a part of the JRAS by a Research Grant from the Japan Agency for Medical Research and Development (AMED) under Grant Number JP19ek010935.

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Correspondence to Noriko Kimura.

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This study was approved by the National Hospital Organization Hakodate Hospital IRB protocol.

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Kimura, N. Dopamine β-hydroxylase: An Essential and Optimal Immunohistochemical Marker for Pheochromocytoma and Sympathetic Paraganglioma. Endocr Pathol 32, 258–261 (2021). https://doi.org/10.1007/s12022-020-09655-w

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