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Channel Blockers of Ionotropic Glutamate Receptors

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Abstract

Glutamatergic transmission is responsible for most of excitatory synaptic processes in the central nervous system of vertebrates. Glutamatergic synapses are involved in the vast majority of physiological and pathological processes, and their modulation has a direct impact on almost all brain functions. It is not surprising that the development and research of drugs that can affect the glutamatergic synapses has been and remains one of the priorities of neuropharmacology. Even a brief overview of this complex problem cannot fit into a single article, so the review focuses on only one of the topics, namely, the ligands which directly block the ion pores of glutamate-activated channels.

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This review has been supported by State budget funding within a State assignment to Sechenov Institute of Evolutionary Physiology and Biochemistry.

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  1. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    D. B. Tikhonov

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Russian Text © The Author(s), 2021, published in Rossiiskii Fiziologicheskii Zhurnal imeni I.M. Sechenova, 2021, Vol. 107, Nos. 4–5, pp. 403–416https://doi.org/10.31857/S0869813921040142.

Translated by A. Polyanovsky

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Tikhonov, D.B. Channel Blockers of Ionotropic Glutamate Receptors. J Evol Biochem Phys 57, 325–336 (2021). https://doi.org/10.1134/S0022093021020149

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