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Single-cell multiomics to probe relationships between histone modifications and transcription

Nature Methods volume 18, pages 602–603 (2021)Cite this article

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Two new technologies enable the profiling of single cells for RNA transcription as well as modifications to histone proteins. Each takes a similar strategy to capture both properties, but with different methods for cell indexing, and they are applied to two different areas: neuroscience and developmental biology, respectively.

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Fig. 1: Paired-Tag and CoTECH to simultaneously profile histone modifications and transcription in single cells.

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Authors and Affiliations

  1. Department of Molecular & Medical Genetics, Knight Cardiovascular Institute, Knight Cancer Institute, and Cancer Early Detection Advanced Research Institute, Oregon Health & Science University, Portland, OR, USA

    Andrew C. Adey

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  1. Andrew C. Adey
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Correspondence to Andrew C. Adey.

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The author declares no competing interests.

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Adey, A.C. Single-cell multiomics to probe relationships between histone modifications and transcription. Nat Methods 18, 602–603 (2021). https://doi.org/10.1038/s41592-021-01147-x

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