Abstract
This work presents the design of a front-end MEMS piezoresistive pressure sensor readout circuit along with a drug actuator model based on TSMC 0.18 μm CMOS technology. The overall system finds application in implantable systems based on micro-pressure sensing and actuation such as the closed loop automatic micturition chip. The system consists of high performance and ultra-low noise chopper stabilized differential amplifier front-end, a digitally programmable threshold generator and window comparator circuit for setting up the pressure thresholds for urination, and an actuator model that simulates drug delivery for micturition, overactive bladder control, and bladder closure. The system also has a novel core circuit enable for power savings mode. The corresponding sub-circuits have been designed to operate in low power that is suitable for implantation and be powered by energy harvesters.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Al Adem KM et al (2017) Implantable systems for stress urinary incontinence. Ann Biomed Eng 45(12):2717–2732. https://doi.org/10.1007/s10439-017-1939-9
Boyer S, Sawan M, Abdel-Gawad M, Robin S, Elhilali MM (2000) Implantable selective stimulator to improve bladder voiding: design and chronic experiments in dogs. IEEE Trans Rehabil Eng 8(4):464–470
Bruinstroop J (2006) Method for controlling micturition. Patent No.: EP1889612 A2
Bullis K (2007) Delivering drugs with MEMS. MIT Technology Review. Retrieved from: https://www.technologyreview.com/s/409122/delivering-drugs-with-mems/ Retrieved on: June 9, 2018
Cao H, Tata U, Landge V, Li AL, Peng YB, Chiao JC (2013) A wireless bladder volume monitoring system using a flexible capacitance-based sensor. In: Proceedings of the 2013 IEEE Topical Conference on biomedical wireless technologies, networks, and sensing systems (BioWireleSS). https://doi.org/10.1109/BioWireleSS.2013.6613666
Chen SC, Chu PY, Hsieh TH, Li YT, Peng CW (2017) Feasibility of deep brain stimulation for controlling the lower urinary tract functions: an animal study. Clin Neurophysiol 128(12):2438–2449. https://doi.org/10.1016/j.clinph.2017.09.102
Dakurah MN, Koo C, Choi WS, Young YH (2015) Implantable bladder sensors: a methodological review. Int Neurourol J 19:133–141
Eldabe S, Buchser E, Duarte RV (2016) Complications of spinal cord stimulation and peripheral nerve stimulation techniques: a review of the literature. Pain Med 17(2):325–336. https://doi.org/10.1093/pm/pnv025
Hsu CC, Chuang YC, Chancellor MB (2013) Intravesical drug delivery for dysfunctional bladder—review article. Int J Urol 20:552–562. https://doi.org/10.1111/iju.12085
Mayo Clinic (2019) Urinary incontinence, Retrieved from: https://www.mayoclinic.org/diseases-conditions/urinary-incontinence/diagnosis-treatment/drc-20352814. Retrieved on: August 11, 2019
Nordqvist C (2018) Urinary Incontinence: What you need to know. Retrieved from: https://www.medicalnewstoday.com/articles/165408.php. Retrieved on: June 8, 2018
“Nova Sensor P162 - Medical Silicon Gage Pressure Sensor Die” (2015) Retrieved from: https://www.amphenol-sensors.com/en/novasensor/pressure-sensor-die/3164-novasensor-p162-medical-silicon-gage-pressure-sensor-die#specifications. Retrieved on: June 9, 2015
Peng SY (2012) Power-efficient reconfigurable analog front-end circuits for sensor and biomedical applications. Lecture Notes. National Taiwan University of Science and Technology
Rajagopalan S, Sawan M, Ghafar-Zadeh E, Savadogo O, Chodavarapu VP (2008) A polypyrrole-based strain sensor dedicated to measure bladder volume in patients with urinary dysfunction. Sensors (Basel) 8(8):5081–5095
Sun J et al (2017) Micro EEG/ECG signal’s chopper-stabilization amplifying chip for novel dry- contact electrode. J Semiconduct 38(2):1–9
Tsai VFS, Silverio AA, Chung WY, Cheng CY, Wang HL, Kung CM, Chen J (2015) The potential of at-home prediction of the formation of urolithiasis by simple multi-frequency electrical conductivity of the urine and the comparison of its performance with urine ion-related indices, color and specific gravity. J Urolithiasis 44(2):217–134
Urology Care Foundation (2019) What is bladder dysfunction? Retrieved from: https://www.urologyhealth.org/urologic-conditions/bladder-dysfunction-and-urine-control-in-children. Retrieved on: August 11, 2019
What Is Electrical Stimulation for Overactive Bladder? (2018) Retrieved from: https://www.webmd.com/urinary-incontinence-oab/overactive-bladder-electrical-stimulation#1. Retrieved on: June 8, 2018
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Silverio, A.A., Silverio, L.A.A. & Silverio, A.A. Design of a urinator system with sensor front-end readout and drug delivery actuator based on TSMC 0.18 μm technology. Microsyst Technol 28, 867–882 (2022). https://doi.org/10.1007/s00542-021-05226-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00542-021-05226-z