Abstract
Astroblastoma is an extremely rare brain tumor that has recently attracted attention owing to its association with MN1 gene alteration. However, its long-term clinical course remains unclear. We report a late recurrence of MN1-altered astroblastoma with unique pathological findings. A 24-year-old woman presented with seizures due to a left frontal lobe tumor. Gross total resection (GTR) was achieved, and the diagnosis was MN1-altered astroblastoma, which presented cell wrapping, i.e., presence of tumor cells enveloping one another. She received local radiotherapy (50 Gy). However, the tumor recurred after 12 years, and its size increased rapidly. The second surgery achieved GTR and confirmed increasing anaplasia. The patient was tumor-free for 1 year without any neurological deficits. This case implies the importance of long-term follow-up of MN1-altered astroblastoma. The pathological significance of cell wrapping in this case is unclear, but it may be associated with MN1-altered astroblastoma and should be noted in future cases.
Similar content being viewed by others
References
Ahmed KA, Allen PK, Mahajan A, Brown PD, Ghia AJ (2014) Astroblastomas: A Surveillance, Epidemiology, and End Results (SEER)-Based Patterns of Care Analysis. World Neurosurg 82:e291–e297
Bell JW, Osborn AG, Salzman KL, Blaser SI, Jones BV, Chin SS (2007) Neuroradiologic characteristics of astroblastoma. Neuroradiology 49:203–209
Brat DJ, Hirose Y, Cohen KJ, Feuerstein BG, Burger PC (2000) Astroblastoma: Clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. Brain Pathol 10:342–352
Chen W, Soon YY, Pratiseyo PD, Sutanto R, Hendriansyah L, Kuick CH, Chang KTE, Tan CL (2020) Central nervous system neuroepithelial tumors with MN1-alteration: an individual patient data meta-analysis of 73 cases. Brain Tumor Pathol 37:145–153
Hirose T, Nobusawa S, Sugiyama K, Amatya VJ, Fujimoto N, Sasaki A, Mikami Y, Kakita A, Tanaka S, Yokoo H (2018) Astroblastoma: a distinct tumor entity characterized by alterations of the X chromosome and MN1 rearrangement. Brain Pathol 28:684–694
Ho CY, Vandenbussche CJ, Huppman AR, Chaudhry R, Ali SZ (2015) Cytomorphologic and clinicoradiologic analysis of primary nonhematologic central nervous system tumors with positive cerebrospinal fluid. Cancer Cytopathol 123:123–135
Janz C, Buhl R (2014) Astroblastoma: report of two cases with unexpected clinical behavior and review of the literature. Clin Neurol Neurosurg 125:114–124
Lehman NL, Usubalieva A, Lin T, Allen SJ, Tran QT, Mobley BC, McLendon RE, Schniederjan MJ, Georgescu MM, Couce M, Dulai MS, Raisanen JM, Abbadi MA, Palmer CA, Hattab EM, Orr BA (2019) Genomic analysis demonstrates that histologically-defined astroblastomas are molecularly heterogeneous and that tumors with MN1 rearrangement exhibit the most favorable prognosis. Acta Neuropathol Commun 7:42
Louis DN, Ohgaki H, Wiestler OD, Cavanee WK, Ellison DW, Figarella-Branger D, et al (2016) World Health Organization Classification of Tumors of the Central Nervous System. revised 4t. Lyon, France
Mhatre R, Sugur HS, Nandeesh BN, Chickabasaviah Y, Saini J, Santosh V (2019) MN1 rearrangement in astroblastoma: study of eight cases and review of literature. Brain Tumor Pathol 36:112–120
Sturm D, Orr BA, Toprak UH et al (2016) New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell 164:1060–1072
Sughrue ME, Choi J, Rutkowski MJ, Aranda D, Kane AJ, Barani IJ, Parsa AT (2011) Clinical features and post-surgical outcome of patients with astroblastoma. J Clin Neurosci 18:750–754
Wood MD, Tihan T, Perry A, Chacko G, Turner C, Pu C, Payne C, Yu A, Bannykh SI, Solomon DA (2018) Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. Brain Pathol 28:192–202
Acknowledgements
The authors would like to thank Enago (www.enago.jp) for the English language review.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interests
The authors declare here that there is no financial support or relationship that may pose a conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Ujihara, M., Mishima, K., Sasaki, A. et al. Unique pathological findings of astroblastoma with MN1 alteration in a patient with late recurrence. Brain Tumor Pathol 38, 243–249 (2021). https://doi.org/10.1007/s10014-021-00401-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10014-021-00401-6