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Ardisiatetrons A and B: tetronic acid derivatives and triterpenes from the leaves of Ardisia quinquegona and their biological activity

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Abstract

From the leaves of Ardisia quinquegona, two alkylated tetronic acid derivatives, named ardisiatetrons A and B (1, 2), and four triterpenoids (3–6) were isolated together with one known compound (7) by a combination of various kinds of chromatography. The structure of new methyl migrated triterpene (3) was confirmed by X-ray crystallographic analysis. Compounds 2, 3, and 7 showed moderate anti-Leishmania activity and cytotoxicity towards A549 cells.

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Acknowledgements

The authors are grateful for access to the mass spectrometer, an Applied Biosystem QSTAR XL system ESI (Nano Spray)-MS at the Analysis Center of Life Science of the Graduate School of Biomedical Sciences, Hiroshima University. This work was supported in part by Grants-in-Aid from the Ministry of Education, Science, Sports, Culture and Technology of Japan, and the Japan Society for the Promotion of Science (Nos. 22590006, 23590130, and 15H04651).

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Authors and Affiliations

  1. Faculty of Pharmacy, Yasuda Women’s University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan

    Susumu Kawakami, Misaki Ishinaka, Masanori Inagaki, Motohiro Nishimura & Hideaki Otsuka

  2. Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan

    Shintaro Asaumi, Sachiko Sugimoto & Hideaki Otsuka

  3. Subtropical Field Science Center, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara-cho, Nakagami-gun, Okinawa, 903-0213, Japan

    Takakazu Shinzato

  4. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Kagawa Campus, 1314-1 Shido, Sanuki-shi, Kagawa, 769-2193, Japan

    Tadashi Hyodo & Kentaro Yamaguchi

Authors
  1. Susumu Kawakami
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  2. Misaki Ishinaka
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  3. Shintaro Asaumi
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  4. Sachiko Sugimoto
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  5. Masanori Inagaki
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  6. Motohiro Nishimura
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  7. Katsuyoshi Matsunami
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  8. Hideaki Otsuka
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  9. Takakazu Shinzato
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  10. Tadashi Hyodo
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  11. Kentaro Yamaguchi
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Corresponding author

Correspondence to Hideaki Otsuka.

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Kawakami, S., Ishinaka, M., Asaumi, S. et al. Ardisiatetrons A and B: tetronic acid derivatives and triterpenes from the leaves of Ardisia quinquegona and their biological activity. J Nat Med 75, 643–654 (2021). https://doi.org/10.1007/s11418-021-01513-1

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  • DOI: https://doi.org/10.1007/s11418-021-01513-1

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