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Annual Review of Immunology

Volume 39, 2021

IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry

Abstract

The IL-17 family is an evolutionarily old cytokine family consisting of six members (IL-17A through IL-17F). IL-17 family cytokines signal through heterodimeric receptors that include the shared IL-17RA subunit, which is widely expressed throughout the body on both hematopoietic and nonhematopoietic cells. The founding family member, IL-17A, is usually referred to as IL-17 and has received the most attention for proinflammatory roles in autoimmune diseases like psoriasis. However, IL-17 is associated with a wide array of diseases with perhaps surprisingly variable pathologies. This review focuses on recent advances in the roles of IL-17 during health and in disease pathogenesis. To decipher the functions of IL-17 in diverse disease processes it is useful to first consider the physiological functions that IL-17 contributes to health. We then discuss how these beneficial functions can be diverted toward pathogenic amplification of deleterious pathways driving chronic disease.

Keyword(s): autoimmunity, cancer, fibrosis, IL-17, microbiota, stromal cells, wound healing
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/content/journals/10.1146/annurev-immunol-101819-092536
2021-04-26
2024-04-25
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/content/journals/10.1146/annurev-immunol-101819-092536
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IL-17 in the Pathogenesis of Disease: Good Intentions Gone Awry
Annual Review of Immunology 39, 537 (2021); https://doi.org/10.1146/annurev-immunol-101819-092536
/content/journals/10.1146/annurev-immunol-101819-092536
/content/journals/10.1146/annurev-immunol-101819-092536
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