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Synthesis and Biological Activity Studies of Novel Pyrido[2,3-d]pyrimidines and Pyrido[2,3-d]triazines

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Abstract

Novel derivatives of pyrido[2,3-d]pyrimidin-2,4(1H,3H)-dithione, 2,3-dimethylpyrido[2,3-d]pyrimidin-4-one, 4-chloro-2-methypyrido[2,3-d]pyrimidine and pyrido[2,3-d]1,2,3 triazin-4-one were synthesized and screened for their anti-microbial and cytoxic activities. 5,7-diphenyl-pyrido[2,3-d]pyrimidin-2,4(1H,3H)-dithione, 5-(4-methoxyphenyl)-7-phenyl-pyrido[2,3-d]pyrimidin-2,4(1H,3H)–dithione, 5,7-diphenyl-2,3-dimethylpyrido[2,3-d]pyrimidin-4-one, 4-chloro-5,7-diphenyl-2-methypyrido[2,3-d]pyrimidine, 4-chloro-7-(4-chlorophenyl)-5-phenyl-2-methypyrido[2,3-d]pyrimidine, 5,7-diphenyl-3,4-dihydropyrido[2,3-d]1,2,3-triazin-4-one, 5-(4-methoxyphenyl)-7-phenyl-3,4-dihydropyrido[2,3-d]1,2,3-triazin-4-one and 7-(4-chlorophenyl)-5-phenyl-3,4-dihydropyrido[2,3-d]1,2,3-triazin-4-one showed excellent anti-microbial activities against all the tested bacteria and fungi compared to the reference drugs. Furthermore, they exhibited high safety profile in cytotoxicity test except 5,7-diphenyl-2,3-dimethylpyrido[2,3-d]pyrimidin-4-one and 4-chloro-7-(4-chlorophenyl)-5-phenyl-2-methypyrido[2,3-d]pyrimidine. The structures of the newly synthesized compounds were confirmed by spectral data and elemental analysis.

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ACKNOWLEDGMENTS

The authors would like to acknowledge Dr. Doaa Ghareeb, Biochemistry Department, Faculty of Science, Alexandria University for her help in biological activity work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Alexandria University, Alexandria, Egypt

    Samir Kamel Elsaedany

  2. Department of Chemistry, Faculty of Science, Damanhour University, Damanhour, Egypt

    Mohamed AbdEllatif zein, Elsayed Mohmoud AbdElRehim & Reda Mohammed Keshk

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  1. Samir Kamel Elsaedany
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  2. Mohamed AbdEllatif zein
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  3. Elsayed Mohmoud AbdElRehim
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  4. Reda Mohammed Keshk
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Correspondence to Reda Mohammed Keshk.

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Elsaedany, S.K., AbdEllatif zein, M., AbdElRehim, E.M. et al. Synthesis and Biological Activity Studies of Novel Pyrido[2,3-d]pyrimidines and Pyrido[2,3-d]triazines. Russ J Bioorg Chem 47, 552–560 (2021). https://doi.org/10.1134/S1068162021020114

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