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Effect of Pre-Treatment with Acetaminophen on Hippocampal Oxidative, Inflammatory, and Apoptotic Parameters in PTZ-Induced Acute Seizure Mice Model

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Abstract

The current investigation aimed to determine the effects of pre-treatment of acetaminophen on seizure susceptibility and expressions of hippocampal oxidative-nitrosative stress and inflammatory markers after exposure to pentylenetetrazole administration in a mouse model. The seizure symptoms of pentylenetetrazole-treated mice were assessed using Racine classification and latency to first myoclonic jerk. Then, several parameters including TAS, TOS, NO, TNF-α, caspase-3, GABA, and glutamate levels were quantitated by commercial kits. The pre-treatment of acetaminophen significantly suppressed pentylenetetrazole-induced seizures. Also, it significantly increased the TAS and GABA values and significantly decreased the TOS, NO, TNF-α, caspase-3, and glutamate values in the hippocampus. These findings are indicative of the antiseizure potential of pre-treatment with acetaminophen in the pentylenetetrazole-induced acute seizure model of epilepsy. This effect may be due to its impact on antioxidant, anti-inflammatory, and anti-apoptotic pathways.

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REFERENCES

  1. Fisher, R. S., Acevedo, C., and Arzimanoglou, A., Bogacz, A., Cross, J.H., Elger, C.E., Engel, J., Jr., Forsgren, L., French, J.A., Glynn, M., Hesdorffer, D.C., Lee, B.I., Mathern, G.W., Moshé, S.L., Perucca, E., Scheffer, I.E., Tomson, T., Watanabe, M., and Wiebe, S., Epilepsia, 2014, vol. 55, no. 4, pp. 475–478.

    Article  Google Scholar 

  2. Chen, Z., Brodie, M. J., Liew, D., and Kwan P., JAMA Neurology, 2018, vol. 75, no. 3, pp. 279–286.

    Article  Google Scholar 

  3. Eastman, C. L., and D’Ambrosio, R., and Ganesh, T. T, Neuropharmacology, 2019, vol. 6, pp. 107907.

    Google Scholar 

  4. Vezzani, A., French, J., Bartfai, T., and Baram, T. Z. Nature Reviews Neurology, 2011, vol. 7, no. 1, pp. 31–40.

    Article  CAS  Google Scholar 

  5. Dhir, A. Expert Opin. Investig. Drugs, 2019, vol. 28, no. 2, pp. 191–205.

    Article  CAS  Google Scholar 

  6. Pearson-Smith, J.N., and Patel, M. Int. J. Mol. Sci., 2017, vol. 18, pp. E2365.

    Article  Google Scholar 

  7. Paudel, Y. N., Shaikh, M. F., Chakraborti, A., and Kumari Y., Front. Neurosci., 2018, vol. 12, no. 628, pp. 1–19.

    Article  Google Scholar 

  8. Naziroğlu, M., Uğuz, A. C., Koçak, A., and Bal, R. J. Membr. Biol., 2009, vol. 231, pp. 57–64.

    Article  Google Scholar 

  9. Courad, J. P., Besse, D., Delchambre, C., Hanoun N., Hamon M., Eschalier F., Caussade F., and Cloarec A., Life Sci., 2001, vol. 69, no. 12, pp. 1455–1464.

    Article  CAS  Google Scholar 

  10. Kumpulainen, E., Kokki, H., Halonen, T., Heikkinen M., Savolainen J., and Laisalmi M., Pediatrics, 2007, vol. 119, no. 4, pp. 766–771.

    Article  Google Scholar 

  11. Wallenstein, M.C. Arch. Int. Pharmacodyn. Ther., 1985, vol. 275, no. 1, pp. 93–104.

    CAS  PubMed  Google Scholar 

  12. Deshpande, L. S. and DeLorenzo, R. J., Neuroreport, 2011, vol. 22, no. 1, pp. 15–18.

    Article  CAS  Google Scholar 

  13. Suemaru, K., Yoshikawa, M., Tanaka, A., Araki, H., Aso, H., Watanabe, M., Epilepsy Res., 2018, vol. 140, pp. 22–28.

    Article  CAS  Google Scholar 

  14. Maharaj, H., Maharaj, D. S., Saravanan, K. S., Mohanakumar, K. P., and Daya, S., Metab. Brain Dis., 2004, vol. 19, pp. 71–77.

    Article  CAS  Google Scholar 

  15. Maharaj, H., Maharaj, D. S., and Daya, S., Life Sci., 2006, vol. 78, no. 21, pp. 2438–2443.

    Article  CAS  Google Scholar 

  16. Tripathy, D. and Grammas, P., Microvasc. Res., 2009, vol. 77, no. 21, pp. 289–296.

    Article  CAS  Google Scholar 

  17. Shin, E. J., Jeong, J. H., and Chung, Y. H. et al., Neurochem. Int., 2011, vol. 59, no. 2, pp. 122–137.

    Article  CAS  Google Scholar 

  18. Erel, O., Clin. Biochem., 2004, vol. 37, no. 4, pp. 277–285.

    Article  CAS  Google Scholar 

  19. Erel, O., Clin Biochem. 2005, vol. 38, no. 12, pp. 1103–1111.

    Article  CAS  Google Scholar 

  20. Högestätt, E. D., Jönsson, B. A., and Ermund, A., Andersson, D.A., Björk, H., Alexander, J.P., Cravatt, B.F., Basbaum, A.I., Zygmunt, P.M., J. Bio. Chem., 2005, vol. 280, no. 36, pp. 31405–31412.

    Article  Google Scholar 

  21. Solbrig, M. V., Adrian, R., Baratta, J., Piomelli, D., and Giuffrida, A. Exp. Neurol., 2005, vol. 194, no. 2, pp. 355–362.

    Article  CAS  Google Scholar 

  22. Shubina, L., Aliev, R., and Kitchigina, V., Brain Res., 2017, vol. 1661, pp. 1–14.

    Article  CAS  Google Scholar 

  23. Kovacs, R., Rabanus, A., Otahal, J., Patzak, A., Kardos, J., Albus, K., Heinemann, U., and Kann, O., J. Neurosci., 2009, vol. 29, no. 26, pp. 8565–8577.

    Article  CAS  Google Scholar 

  24. Watanabe, M., Miyai, A., Danjo, S., Nakamura, Y., and Itoh, K., Exp. Neurol., 2013, vol. 247, pp. 645–652.

    Article  CAS  Google Scholar 

  25. Björkman, R., Hallman, K. M., Hedner, J., Hedner, T., and Henning, M., Pain, 1994, vol. 57, pp. 259–264.

    Article  Google Scholar 

  26. Glibetic, M., Parker, J., and Aranda, J., Ped. Res., 1999, vol. 45, p. 66

    Article  Google Scholar 

  27. Galic, M. A., Riazi, K., and Pittman, Q. J., Front. Neuroendocrinol., 2012 vol. 33, no. 1, pp. 116–125.

    Article  CAS  Google Scholar 

  28. Stellwagen, D., J. Neurosci., 2005, vol. 25, no. 12, pp. 3219–3228.

    Article  CAS  Google Scholar 

  29. Nastevska, C., Gerber, E., Horbach, M., Röhrdanz, E., and Kahl, R., Toxicology, 1999, vol. 15, no. 133, pp. 85–92.

    Article  Google Scholar 

  30. Young, C., Roth, K.A., Klocke, B.J., West, T., Holtzman, D.M., Labruyere, J., Qin, Y.Q., Dikranian, K., and Olney, J.W., Neurobiol. Dis., 2005, vol. 20, no. 2, pp. 608–614.

    Article  CAS  Google Scholar 

  31. Henshall, D.C., Clark, R.S., Adelson, P.D., Chen, M., Watkins, S.C., and Simon, R.P., Neurology, 2000, vol. 55, no. 2, pp. 250–257.

    Article  CAS  Google Scholar 

  32. Ali, A.E., Mahdy, H.M., Elsherbiny, D.M., Azab, S.S., Biochem. Pharmacol., 2018, vol. 156, pp. 431–443.

    Article  CAS  Google Scholar 

  33. Gillardon, F., Bottiger, B., Schmitz, B., Zimmermann, M., and Hossmann, K.A., Mol. Brain Res., 1997, vol. 50, pp. 16–22.

    Article  CAS  Google Scholar 

  34. Faherty, C.J., Xanthoudakis, S., and Smeyne, R.J., Mol. Brain Res., 1999, vol. 70, no. 1, pp. 159–163.

    Article  CAS  Google Scholar 

  35. Tripathy, D., and Grammas, P., J. Neuroinflamm., 2009, vol. 6, pp. 1–10.

    Article  Google Scholar 

  36. Dambach, D.M., Durham, S.K., Laskin, J.D., and Laskin, D.L., Toxicol. Appl. Pharmacol., 2006, vol. 211, no. 2, pp. 157–165.

    Article  CAS  Google Scholar 

  37. Pires, L.F., Costa, L.M., de Almeida, A.A., Silva, O.A., Cerqueira, G.S., de Sousa, D.P., Pires, R.M.C., Satyal, P., and de Freitas, R.M., Chemico-Biol. Int., 2015, vol. 226, pp. 49–57.

    CAS  Google Scholar 

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ACKNOWLEDGMENTS

We would like to thank Prof. Ali Cetin, MD, Sivas Cumhuriyet University, Sivas, Turkey, for valuable comments on the manuscript.

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The authors did not receive support from any organization for the submitted work.

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Authors and Affiliations

  1. Department of Medical Services and Techniques, Vocational School of Health Services, Sivas Cumhuriyet University, TR-58140, Sivas, Turkey

    S. Karabulut

  2. Department of Medical Physiology, Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey

    A. S. Taskiran

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  1. S. Karabulut
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Correspondence to S. Karabulut.

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Conflict of interest. The authors declared no conflict of interest.

Ethical approval. All procedures were conducted in accordance with the guidelines of the Cumhuriyet University Animal Ethics Committee for the welfare of experimental animals (Registry no. 65202830-050.04.04-385 dated 09.03.2020).

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Karabulut, S., Taskiran, A.S. Effect of Pre-Treatment with Acetaminophen on Hippocampal Oxidative, Inflammatory, and Apoptotic Parameters in PTZ-Induced Acute Seizure Mice Model. Neurochem. J. 15, 79–85 (2021). https://doi.org/10.1134/S1819712421010050

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