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Peripheral Markers of Nervous Tissue Damage in Addictive and Affective Disorders

  • CLINICAL NEUROCHEMISTRY
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Abstract—Studies on the pathophysiology of mental disorders indicate the involvement of neurobiological processes, including the neuroinflammatory response, neurogenesis, and neuronal degeneration, in the mechanisms of development of these disorders. We examined 135 patients with addictive and affective disorders (51 patients with alcohol dependence syndrome, 41 patients with a current depressive episode and 43 patients with comorbidity of alcohol dependence syndrome and affective disorder) and 46 mentally healthy donors. The content of neurospecific proteins (NSE, MBP, and GFAP) in the blood serum of patients and healthy people was determined by enzyme-linked immunosorbent assay. The study of peripheral markers of nerve tissue damage showed that all patients are characterized by signs of neuronal and glial distress. The results of analysis of variance and ROC analysis indicate the contribution of NSE and MBP to the development of affective disorders, while GFAP has a greater predictive efficiency in the case of addictive pathology. The tendency towards imbalance in the secretion of neurospecific proteins in the blood serum of patients with comorbidity of alcohol dependence and affective disorders is enhanced, which probably indicates a greater defect in neurobiological processes and neurodegeneration, and is also confirmed by data showing more severe clinical symptoms of patients in these cases of comorbidity.

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Funding

This work was supported by the Russian Science Foundation, project no. 19-15-00023 “Clinical Features and the Search for Potential Biomarkers of Comorbidity of Alcoholism and Affective Disorders.”

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Correspondence to L. A. Levchuk.

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Conflict of interests. The authors declare that they have no conflicts of interest.

Ethical approval. All procedures performed in the study with human participation comply with the ethical standards approved by the biomedical ethics committee of the Mental Health Research Institute of the Tomsk National Research Medical Center and the 1964 Helsinki Declaration and its subsequent amendments or comparable ethical standards.

Informed consent. Informed voluntary consent was obtained from each of the participants included in the study.

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Levchuk, L.A., Roshchina, O.V., Simutkin, G.G. et al. Peripheral Markers of Nervous Tissue Damage in Addictive and Affective Disorders. Neurochem. J. 15, 86–90 (2021). https://doi.org/10.1134/S1819712421010074

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  • DOI: https://doi.org/10.1134/S1819712421010074

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