Clinical Characteristics and Outcomes of Hospitalized Patients With Heart Failure From the Large-Scale Japanese Registry Of Acute Decompensated Heart Failure (JROADHF)

Tomomi Ide; Hidetaka Kaku; Shouji Matsushima; Takeshi Tohyama; Nobuyuki Enzan; Kouta Funakoshi; Yoko Sumita; Michikazu Nakai; Kunihiro Nishimura; Yoshihiro Miyamoto; Miyuki Tsuchihashi-Makaya; Masaru Hatano; Issei Komuro; Hiroyuki Tsutsui; the JROADHF Investigators

doi:10.1253/circj.CJ-20-0947

Acute Heart Failure

Clinical Characteristics and Outcomes of Hospitalized Patients With Heart Failure From the Large-Scale Japanese Registry Of Acute Decompensated Heart Failure (JROADHF)

Tomomi Ide, Hidetaka Kaku, Shouji Matsushima, Takeshi Tohyama, Nobuyuki Enzan, Kouta Funakoshi, Yoko Sumita, Michikazu Nakai, Kunihiro Nishimura, Yoshihiro Miyamoto, Miyuki Tsuchihashi-Makaya, Masaru Hatano, Issei Komuro, Hiroyuki Tsutsui, the JROADHF Investigators

Author information

Tomomi Ide
Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University [Japan]
Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University [Japan]
Hidetaka Kaku
Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University [Japan]
Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University [Japan]
Shouji Matsushima
Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University [Japan]
Takeshi Tohyama
Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University [Japan]
Center for Clinical and Translational Research, Kyushu University Hospital [Japan]
Nobuyuki Enzan
Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University [Japan]
Kouta Funakoshi
Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University [Japan]
Center for Clinical and Translational Research, Kyushu University Hospital [Japan]
Yoko Sumita
Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center [Japan]
Michikazu Nakai
Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center [Japan]
Kunihiro Nishimura
Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center [Japan]
Yoshihiro Miyamoto
Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center [Japan]
Miyuki Tsuchihashi-Makaya
School of Nursing, Kitasato University [Japan]
Masaru Hatano
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo [Japan]
Issei Komuro
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo [Japan]
Hiroyuki Tsutsui
Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University [Japan]
Division of Cardiovascular Medicine, Research Institute of Angiocardiology, Faculty of Medical Sciences, Kyushu University [Japan]
the JROADHF Investigators

Keywords: Aging population, Heart failure, Heart failure with preserved ejection fraction, Outcomes, Registry

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Supplementary material

2021 Volume 85 Issue 9 Pages 1438-1450

DOI https://doi.org/10.1253/circj.CJ-20-0947

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Abstract

Background:With aging population, the prevalence and incidence of heart failure (HF) have been increasing worldwide. However, the characteristics and outcomes of patients with HF in an era of aging are not well established in Japan.

Methods and Results:The Japanese Registry Of Acute Decompensated Heart Failure (JROADHF), a retrospective, multicenter, nationwide registry, was designed to study the clinical characteristics and outcomes of patients hospitalized with HF throughout Japan in 2013. One hundred and twenty-eight hospitals were selected by cluster random sampling and 13,238 hospitalized patients with HF were identified by medical record review. Demographics, medical history, severity, treatment, and in-hospital and long-term outcome data were collected from the Diagnostic Procedure Combination and medical charts. Data were analyzed using univariate and multivariate logistic regression or Cox regression analysis. The mean age of registered patients was 78.0±12.5 years and 52.8% were male. Elderly patients (age >75 years) accounted for 68.9%, and HF with preserved ejection fraction (HFpEF) accounted for 45.1%. Median length of hospital stay was 18 days and in-hospital mortality was 7.7%. The median follow-up period was 4.3 years, and the incidence rates for cardiovascular death and rehospitalization for HF were 7.1 and 21.1 per 100 person-years, respectively.

Conclusions:A contemporary nationwide registry demonstrated that hospitalized HF patients were very elderly, HFpEF was common, and their prognosis was still poor in Japan.

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