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Late-life cynical hostility is associated with white matter alterations and the risk of Alzheimer's disease

Published online by Cambridge University Press:  14 April 2021

Fabienne Cyprien ,
Claudine Berr ,
Jerome J. Maller ,
Chantal Meslin ,
Mélissa Gentreau ,
Thibault Mura ,
Audrey Gabelle ,
Philippe Courtet ,
Karen Ritchie  and
Marie-Laure Ancelin
...Show all authors
Fabienne Cyprien
Affiliation:
IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France CHU Montpellier, Montpellier, France
Claudine Berr
Affiliation:
INM, Univ Montpellier, INSERM, Montpellier, France
Jerome J. Maller
Affiliation:
Monash Alfred Psychiatry Research Centre, The Alfred & Monash University School of Psychology and Psychiatry, Melbourne, Australia
Chantal Meslin
Affiliation:
Centre for Mental Health Research, Australian National University, Canberra, Australia
Mélissa Gentreau
Affiliation:
IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France
Thibault Mura
Affiliation:
INM, Univ Montpellier, INSERM, Montpellier, France CHU Nîmes, Nîmes, France
Audrey Gabelle
Affiliation:
CHU Montpellier, Montpellier, France INM, Univ Montpellier, INSERM, Montpellier, France
Philippe Courtet
Affiliation:
IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France CHU Montpellier, Montpellier, France
Karen Ritchie
Affiliation:
INM, Univ Montpellier, INSERM, Montpellier, France Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK
Marie-Laure Ancelin
Affiliation:
INM, Univ Montpellier, INSERM, Montpellier, France
Sylvaine Artero*
Affiliation:
IGF, Univ Montpellier, CNRS, INSERM, Montpellier, France
*
Author for correspondence: Sylvaine Artero, E-mail: sylvaine.artero@inserm.fr
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Abstract

Background

Cynical hostility (CH), a specific dimension of hostility that consists of a mistrust of others, has been suggested as a high-risk trait for dementia. However, the influence of CH on the incidence of Alzheimer's disease (AD) remains poorly understood. This study investigated whether late-life CH is associated with AD risk and structural neuroimaging markers of AD.

Methods

In community-dwelling older adults from the French ESPRIT cohort (n = 1388), incident dementia rate according to CH level was monitored during an 8-year follow-up and analyzed using Cox proportional hazards regression models. Brain magnetic resonance imaging volumes were measured at baseline (n = 508). Using automated segmentation procedures (Freesurfer 6.0), the authors assessed brain grey and white volumes on all magnetic resonance imaging scans. They also measured white matter hyperintensities volumes using semi-automated procedures. Mean volumes according to the level of CH were compared using ANOVA.

Results

Eighty-four participants developed dementia (32 with AD). After controlling for potential confounders, high CH was predictive of AD (HR 2.74; 95% CI 1.10–6.85; p = 0.030) and all dementia types are taken together (HR 2.30; 95% CI 1.10–4.80; p = 0.027). High CH was associated with white matter alterations, particularly smaller anterior corpus callosum volume (p < 0.01) after False Discovery Rate correction, but not with grey matter volumes.

Conclusions

High CH in late life is associated with cerebral white matter alterations, designated as early markers of dementia, and higher AD risk. Identifying lifestyle and biological determinants related to CH could provide clues on AD physiopathology and avenues for prevention strategies.

Keywords

PersonalityAlzheimer DiseaseCerebral white mattercorpus callosumcohortrisk factor
Type
Original Article
Information
Psychological Medicine , Volume 52 , Issue 15 , November 2022 , pp. 3636 - 3645
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press

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