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Evaluation of Platelet Indices in Patients with Splanchnic Vein Thrombosis

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Abstract

Splanchnic vein thrombosis (SVT) is a rare and lethal form of venous thrombosis. The role of platelet indices (PI’s) is not well studied in SVT. The present study was aimed to assess if the PI’s have a significant association with SVT. This was a prospective case control study from coagulation laboratory of Hematology department. A total 100 cases of SVT and 80 controls were screened for PI’s (MPV, PCT & PDW) and platelet count (PC) along with routine thrombophilic risk factors. The SVT cases were divided into 3 subgroups, that comprised of EHPVO/ PVT (n = 69), BCS (n = 27), and MVT (n = 4). The mean PC and PCT were significantly lower in patients than the controls. The PDW was significantly higher in cases than in the controls and MPV was relatively higher in cases however did not show statistical significance. In addition, 16 patients were found to have deranged thrombophilic risk factors. Among these, 8 cases had inherited risk factors (2: FVL; 5: PC; 1: PS) and 8 cases had acquired risk factors (2: APL; and 5: multiple factors and one case had both FVL mutation and APL positivity). The PDW and PCT together with PC were found to significantly differ in SVT cases than in controls, particularly in idiopathic cases. It may be worthwhile to explore the utility of PI’s as a potential risk factor in SVT.

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Authors and Affiliations

  1. Department of Hematology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India

    Saniya Sharma, Narender Kumar, Ishwar Bihana, Varun Uppal, Jasmina Ahluwalia, Shano Naseem & Neelam Varma

  2. Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Sector 12, Chandigarh, 160012, India

    Surinder Singh Rana

Authors
  1. Saniya Sharma
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  2. Narender Kumar
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  3. Ishwar Bihana
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  4. Varun Uppal
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  5. Jasmina Ahluwalia
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  7. Neelam Varma
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  8. Surinder Singh Rana
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Correspondence to Narender Kumar.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Sharma, S., Kumar, N., Bihana, I. et al. Evaluation of Platelet Indices in Patients with Splanchnic Vein Thrombosis. Indian J Hematol Blood Transfus 37, 593–599 (2021). https://doi.org/10.1007/s12288-021-01400-5

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  • DOI: https://doi.org/10.1007/s12288-021-01400-5

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