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Effect of biological factors on latency of pattern-reversal visual evoked potentials associated with cathode ray tubes and liquid crystal display monitors in normal young subjects

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Abstract

Purpose

Owing to several factors, peak latencies of pattern-reversal visual evoked potentials (p-VEP) are delayed when viewing liquid crystal display (LCD) monitors compared to those evoked when viewing cathode ray tube (CRT) monitors. However, few studies have examined whether biological factors affect latency in LCD. This study aimed to investigate whether biological factors caused latency changes in LCD among young subjects.

Methods

Twenty-eight subjects (56 eyes) aged 21–29 years (mean ± SD, 22.7 ± 1.7) participated in this study. We recorded output from each eye twice for both CRT and LCD monitors under the same conditions for monocular p-VEP. The peak latencies of three components (N75, P100, and N145) were compared between these two monitors.

Results

All peak latencies recorded with LCD were delayed compared to those recorded with CRT: N75, 9.7 ± 2.5 ms; P100, 10.1 ± 3.0 ms; and N145, 8.4 ± 6.2 ms (all p < 0.001). The degree of latency delay varied depending on the components. Moreover, all peak latencies of CRT appeared earlier than standard values of N75, P100, and N145.

Conclusions

These findings suggest that the following aspects should be considered when assessing biological factors that may affect latency: components might influence latency changes; a young age could be related to an early appearance of peak latencies; inter-individual differences might cause latency change. These biological factors should be considered as possible causes for the varying latencies in an LCD monitor. Further studies should include healthy adults with a wider age range to assess the effects of age on latency.

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Data availability

The datasets generated and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors would like to thank the Department of Laboratory Medicine at Shinshu University Hospital. We would also like to express our gratitude towards all the study participants.

Funding

The authors received no specific funding for this work.

Author information

Authors and Affiliations

  1. Department of Medical Laboratory Science, Faculty of Health Sciences, Junshin Gakuen University, 1-1-1, Chikushigaoka, Fukuoka, 815-8510, Japan

    Midori Ura

  2. School of Health Sciences, Shinshu University, Nagano, Japan

    Mutsuki Matsuo

  3. Center for Health Safety and Environmental Management, Shinshu University, Nagano, Japan

    Hiroshi Morita

  4. Department of Laboratory Science, Shinshu University Hospital, Nagano, Japan

    Midori Ura & Haruna Yamazaki

  5. Clinical Laboratory, International University of Health Welfare Narita Hospital, Chiba, Japan

    Mutsuki Matsuo

Authors
  1. Midori Ura
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  2. Mutsuki Matsuo
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  3. Haruna Yamazaki
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  4. Hiroshi Morita
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Contributions

All authors participated in a meaningful way in the preparation of the manuscript. MU designed the study, supervised the collection and interpretation of data, and drafted the manuscript. MM collected and interpreted data. HY interpreted statistical data and created the figures. HM interpreted data and supervised writing the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Midori Ura.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The research was conducted at the Department of Laboratory Medicine, Shinshu University Hospital. All research procedures were approved by the Ethics Committee of Shinshu University, School of Medicine (2770).

Statement of human rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board of the Shinshu Univerisy and we performed in accordance with the 1964 Helsinki Declaration.

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This study does not contain any research on animals.

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Informed consent was obtained from all individual participants included in this study.

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All participants signed an informed consent form regarding the publication of their aggregated, anonymized data, preventing identification of individuals.

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Ura, M., Matsuo, M., Yamazaki, H. et al. Effect of biological factors on latency of pattern-reversal visual evoked potentials associated with cathode ray tubes and liquid crystal display monitors in normal young subjects. Doc Ophthalmol 143, 185–192 (2021). https://doi.org/10.1007/s10633-021-09833-z

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  • DOI: https://doi.org/10.1007/s10633-021-09833-z

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