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Impact of Chronic Oral Administration of Silver Nanoparticles on Cognitive Abilities of Mice

  • RADIOBIOLOGY, ECOLOGY AND NUCLEAR MEDICINE
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Abstract

To assess the effect of silver nanoparticles on mice cognitive abilities, daily, up to 4-month period, experimental mice were administrated with silver nanoparticles solution. Accumulation of silver in brain was assessed by neutron activation analysis. Cognitive abilities in mice before and after silver nanoparticles administration were evaluated in the Morris water maze behavioral test. No significant differences in the amounts of silver accumulated in brain were found between capable and incapable animals. Silver accumulation in brain of experimental animals in 4-months experiment was higher than in 2-months experiment for both groups. In the main Morris water maze behavioral test at the control points of 2 and 4 months no statistically significant differences were found in the parameters of treks between experimental and control animals.

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ACKNOWLEDGMENTS

We are grateful to Dr. Richard B. Hoover for his suggestions that improved the manuscript.

Funding

This work was supported by the Russian Foundation for Basic Research grant no. 15-32-20429 mol_a_ved.

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Authors and Affiliations

  1. Moscow Regional Research and Clinical Institute named after M.F. Vladimirsky, 129110, Moscow, Russia

    A. L. Ivlieva, E. N. Petritskaya, D. A. Rogatkin & A. A. Glazkov

  2. National Research Centre “Kurchatov Institute”, 123182, Moscow, Russia

    V. A. Demin

  3. Joint Institute for Nuclear Research, 141980, Dubna, Moscow oblast, Russia

    I. Zinicovscaia, S. S. Pavlov & M. V. Frontasyeva

  4. Horia Hulubei National Institute for R&D in Physics and Nuclear Engineering, MG-6, Bucharest, Magurele, Romania

    I. Zinicovscaia

  5. Institute of Chemistry of the Academy of Science of Moldova, Chisinau, Moldova

    I. Zinicovscaia

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  1. A. L. Ivlieva
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Correspondence to I. Zinicovscaia.

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Ivlieva, A.L., Petritskaya, E.N., Rogatkin, D.A. et al. Impact of Chronic Oral Administration of Silver Nanoparticles on Cognitive Abilities of Mice. Phys. Part. Nuclei Lett. 18, 250–265 (2021). https://doi.org/10.1134/S1547477121020072

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