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Dose-dependent Effects of Cacao Polyphenol Intake on Lipid Metabolism in Rats

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Abstract

Cacao polyphenols (CPs) are known to suppress the oxidation of low-density lipoprotein and cholesterol absorption. Herein, we examined the impact of CP on the lipid metabolism in rats fed CP-rich chocolate, by analyzing liver weight and histology, via hematoxylin-eosin staining. The high-CP group had significantly lighter livers than the CP-free group. Histologically, the high-CP group showed significantly lower liver fat accumulation than the CP-free group. These results suggest that CPs prevent liver fat accumulation, being potentially useful against obesity and related diseases.

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Authors and Affiliations

  1. Anatomy and Physiology Laboratory, Department of Health and Nutrition, Osaka Shoin Women’s University, 4-2-26 Hishiya-Nishi, Higashi-Osaka, 577-8550, Japan

    Yuka Aono, Takanobu Kaido, Nagisa Kita, Kaho Sugiyama, Maho Sumikawa, Shizuka Nakayama & Yukiko Fukushima

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  1. Yuka Aono
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  2. Takanobu Kaido
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  3. Nagisa Kita
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  4. Kaho Sugiyama
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  5. Maho Sumikawa
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  6. Shizuka Nakayama
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  7. Yukiko Fukushima
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Correspondence to Yuka Aono.

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The study was approved by and conducted according to the guidelines of the ethics committee of the Osaka Shoin Women’s University [IRB No.30–128].

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Aono, Y., Kaido, T., Kita, N. et al. Dose-dependent Effects of Cacao Polyphenol Intake on Lipid Metabolism in Rats. Plant Foods Hum Nutr 76, 254–255 (2021). https://doi.org/10.1007/s11130-021-00893-9

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  • DOI: https://doi.org/10.1007/s11130-021-00893-9

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