Abstract
The apelin receptor (APLNR) is a class A (rhodopsin-like) G-protein coupled receptor with a wide distribution throughout the human body. Activation of the apelin/APLNR system regulates AMPK/PI3K/AKT/mTOR and RAF/ERK1/2 mediated signaling pathways. APLNR activation orchestrates several downstream signaling cascades, which play diverse roles in physiological effects, including effects upon vasoconstriction, heart muscle contractility, energy metabolism regulation, and fluid homeostasis angiogenesis. We consolidated a network map of the APLNR signaling map owing to its biomedical importance. The curation of literature data pertaining to the APLNR system was performed manually by the NetPath criteria. The described apelin receptor signaling map comprises 35 activation/inhibition events, 38 catalysis events, 4 molecular associations, 62 gene regulation events, 113 protein expression types, and 4 protein translocation events. The APLNR signaling pathway map data is made freely accessible through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway:WP5067).
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Acknowledgments
We thank Karnataka Biotechnology and Information Technology Services (KBITS), Government of Karnataka, for the support to Center for Systems Biology and Molecular Medicine at Yenepoya (Deemed to be University) under the Biotechnology Skill Enhancement Programme in Multiomics Technology (BiSEP GO ITD 02 MDA 2017). RDAB is a recipient of the Senior Research Fellowship from the Indian Council of Medical Research (ICMR), Government of India. JKR is grateful for funding from the Canadian Institutes of Health Research (Operating Grant MOP-111138) and Research Nova Scotia (Development and Innovative Grant #MEDI-2019-2022).
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Dagamajalu, S., Rex, D.A.B., Philem, P.D. et al. A network map of apelin-mediated signaling. J. Cell Commun. Signal. 16, 137–143 (2022). https://doi.org/10.1007/s12079-021-00614-6
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DOI: https://doi.org/10.1007/s12079-021-00614-6