Nano-Honokiol ameliorates the cognitive deficits in TgCRND8 mice of Alzheimer’s disease via inhibiting neuropathology and modulating gut microbiota
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open access
Graphical abstract
Keywords
Honokiol nanoscale drug delivery system
TgCRND8 mice
Cognitive deficits
Neuroinflammation
Tau protein hyperphosphorylation
Gut microbiota
Abbreviations
AD
Alzheimer’s disease
Aβ
β-amyloid
APH-1
anterior pharynx-defective-1
APP
amyloid precursor protein
BACE-1
β-site APP cleaving enzyme-1
Bcl-2
B cell lymphoma-2
CDK5
cyclin-dependent kinase 5
CMC-Na
sodium carboxymethylcellulose
GSK-3β
glycogen synthase kinase 3β
HO
Honokiol
HPLC
high performance liquid chromatography
IDE
insulin degrading enzyme
IL-6
interleukin 6
IL-1β
interleukin 1β
PS-1
presenilin-1
JNK
c-Jun N-terminal kinase
MCT
Medium-chain triglycerides
MWMT
Morris Water Maze test
Nano-HO
honokiol nanoscale drug delivery system
NEP
neprilysin
NFTs
neurofibrillary tangles
PBS
phosphate-buffered saline
PDI
poly-dispersity index
ROS
reactive oxygen species
TEM
transmission electron microscope
TNF-α
tumor necrosis factor
WT
wild type
ZP
zeta potential
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Peer review under responsibility of Cairo University.
© 2021 The Authors. Published by Elsevier B.V. on behalf of Cairo University.