Abstract
In this study, we evaluated the biosafety of a novel polyetheretherketone (PEEK) copolymer [P(E2-E4)K] composite using an animal model to test an implanted orthopedic spine cage. The PEEK copolymer was synthesized by solution polymerization with diphenyl sulfone solvent and blended with carbon fibers and graphene oxide to produce the composite. The P(E2-E4)K composite exhibited improved mechanical properties, similar to natural bone. The animal study results for short-term inflammation evaluation by hematoxylin & eosin and immunostaining methods showed significant histochemical stability for 3 weeks after implantation, demonstrating the required biosafety for medical application as an implantable spine cage.
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Y. Li, Z. Wu, X. Li, Z. Guo, S. Wu, Y. Zhang, L. Shi, S. Teoh, Y. Liu, and Z. Zhang, Biomaterials, 35, 5647 (2014).
J. B. Park and R. S. Lakes, in Biomaterials: An Introduction, 3rd ed., Springer, Berlin, 2007, pp 100–136.
D. J. Blackwood, Corros. Rev., 21, 97 (2003).
S. Jain, A. E. M. Eltorai, R. Ruttiman, and A. H. Daniels, Orthop. Surg., 8, 278 (2016).
A. Nanda, M. Sharma, A. Sonig, S. Ambekar, and P. Bollam, World Neurosurg., 82, 1380 (2014).
M. Salahshoor, and Y. Guo, Materials, 5, 135 (2012).
K. P. Baidya, S. Ramakrishna, M. Rahman, and A. Ritchie, J. Biomater. Appl., 15, 279 (2001).
M. K. Steven and N. D. John, Biomaterials, 28, 4845 (2007).
M. T. Jeffey, W. Mei, T. E. Bradley, L. S. Jeffrey, B. S. Howard, and A. S. Turner, Biomaterials, 27, 324 (2006).
N. Shariq, S. Z. Muhammad, K. Zohaib, and S. Fahad, J. Prosthodont. Res., 60, 12 (2016).
J. W. Chon, Y. Xin, S. M. Lee, Y. J. Kim, I. S. Jun, J. Y. Jho, and D. J. Chung, Polymers, 11, 1803 (2019).
ISO 10993-11, International Standard, 3rd ed., 2009.
OECD Guideline for Testing of Chemical No. 406, OECD (1992).
F. Witte, I. Abeln, E. Switzer, V. Kaese, A. Mayer-Lindenberg, and H. J. Windhagen, Biomed. Mater. Res. A, 85, 1041 (2008).
M. F. Arif, S. Kumar, K. M. Varadarajan, and W. J. Cantwell, Mater. Des., 146, 249 (2018).
C. Rivard, S. Rhalmi, and C. Coillard, J. Biomed. Mater. Res., 62, 488 (2002).
Acknowledgments
We appreciate and are grateful to Prof. Jin Ho Kim (Department of Chemistry, Incheon National University, Incheon, 22012, Korea) for providing various novel monomers for this study. This study was supported by the Technology Innovation Program (Project No.; 10062163, Project Title: Developing economical manufacturing techniques for aromatic polyketones and their reinforced composites (compressive strength > 180 MPa) used for medical applications), funded by the Ministry of Trade, Industry & Energy (MOTIE, Korea).
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Supporting information is available for surface analysis results for sections of PEEK composites. The materials are available via the Internet at http://www.springer.com/13233.
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Chon, J.W., Xin, Y., Lee, S.M. et al. In vivo Evaluation of PEEK Copolymer Composites for Prosthetic Spine. Macromol. Res. 29, 244–251 (2021). https://doi.org/10.1007/s13233-021-9027-2
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DOI: https://doi.org/10.1007/s13233-021-9027-2