Journal of Lipid Research
Volume 62, 2021, 100063
Research Article25-Hydroxycholesterol 3-sulfate is an endogenous ligand of DNA methyltransferases in hepatocytes
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Supplementary key words
cholesterol metabolites
oxysterol sulfation
oxysterol
oxysterol sulfate
high glucose
MAPK-ERK signaling
calcium-AMPK signaling
DNMT
CpG methylation
metabolic regulation
Abbreviations
AMPK
AMP-activated protein kinase
CREB
cAMP-response element binding protein
DMR
differentially methylated region
DNMT
DNA methyltransferase
DUSP
dual-specificity phosphatase
25HC
25-hydroxycholesterol
27HC
27-hydroxycholesterol
25HC3S
25-hydroxycholesterol 3-sulfate
27HC3S
27-hydroxycholesterol 3-sulfate
HDAC
histone deacetylase
HG
high glucose
HMGR
3-hydroxy-3-methylglutaryl-coenzyme A reductase
KEGG
Kyoto Encyclopedia of Genes and Genomes
LINE-1
long interspersed nucleotide element 1
5mC
5-methylcytosine
NAFLD
nonalcoholic fatty liver disease
PGC-1α
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Xol
cholesterol
Xol3S
cholesterol 3-sulfate
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© 2021 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.