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Infrared Spectroscopy of Blood Serum from Patients with Oncohematological Diseases

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Abstract

A comparative analysis of the secondary structure of blood serum proteins was carried out in patients with multiple myeloma, chronic lymphocytic leukemia and in healthy donors. The secondary structure of proteins in serum was determined using an infrared spectroscopy method. It was demonstrated that the proposed approach allows one to register a decrease in the portion of α-helical regions and an increase in the number of β-sheets in the blood serum samples of patients with multiple myeloma compared with healthy donors and patients with chronic lymphocytic leukemia.

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ACKNOWLEDGMENTS

A part of the work was carried out using equipment of the resource centers of the research park of St. Petersburg State University (Center for Optical and Laser Materials Research, Center for Diagnostics of Functional Materials for Medicine, Pharmacology and Nanoelectronics, Nanotechnologies, Cryogenic Department).

Funding

This work was supported by the Russian Foundation for Basic Research (grant no. 18-08-01500).

Author information

Authors and Affiliations

  1. Department of Physics, St. Petersburg State University, 199034, Peterhof, St. Petersburg, Russia

    E. A. Telnaya, L. V. Plotnikova & A. M. Polyanichko

  2. Russian Research Institute of Hematology and Transfusiology, Federal Biomedical Agency of Russian Federation, 191024, St. Petersburg, Russia

    A. D. Garifullin, A. Yu. Kuvshinov & S. V. Voloshin

  3. Kirov Military Medical Academy, 194044, St. Petersburg, Russia

    A. D. Garifullin, A. Yu. Kuvshinov & S. V. Voloshin

  4. Mechnikov Northwestern State Medical University, 191015, St. Petersburg, Russia

    A. D. Garifullin, A. Yu. Kuvshinov & S. V. Voloshin

  5. Institute of Cytology, Russian Academy of Sciences, 194064, St. Petersburg, Russia

    A. M. Polyanichko

Authors
  1. E. A. Telnaya
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  2. L. V. Plotnikova
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  3. A. D. Garifullin
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  4. A. Yu. Kuvshinov
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  5. S. V. Voloshin
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  6. A. M. Polyanichko
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Corresponding author

Correspondence to A. M. Polyanichko.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Statement of Compliance with Standards of Research Involving Humans as Subjects

All procedures performed in the study involving human participants were in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments. Informed consent was obtained from all individual participants involved in the study.

Additional information

Translated by A. Barkhash

Abbreviations: MM, multiple myeloma; IR, infrared; CLL, chronic lymphocytic leukemia; ATR, attenuated total reflection.

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Telnaya, E.A., Plotnikova, L.V., Garifullin, A.D. et al. Infrared Spectroscopy of Blood Serum from Patients with Oncohematological Diseases. BIOPHYSICS 65, 981–986 (2020). https://doi.org/10.1134/S0006350920060214

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  • DOI: https://doi.org/10.1134/S0006350920060214

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