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Post-traumatic Headache and Mild Traumatic Brain Injury: Brain Networks and Connectivity

  • Concussion and Head Injury (A Finkel, Section Editor)
  • Published:
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Abstract

Purpose of Review

Post-traumatic headache (PTH) consequent to mild traumatic brain injury (mTBI) is a complex, multidimensional, chronic neurological disorder. The purpose of this review is to evaluate the current neuroimaging studies on mTBI and PTH with a specific focus on brain networks and connectivity patterns.

Recent Findings

We present findings on PTH incidence and prevalence, as well as the latest neuroimaging research findings on mTBI and PTH. Additionally, we propose a new strategy in studying PTH following mTBI.

Summary

The diversity and heterogeneity of pathophysiological mechanisms underlying mild traumatic brain injury pose unique challenges on how we interpret neuroimaging findings in PTH. Evaluating alterations in the intrinsic brain network connectivity patterns using novel imaging and analytical techniques may provide additional insights into PTH disease state and therefore inform effective treatment strategies.

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Authors and Affiliations

  1. Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA

    Nasim Maleki

  2. Carolina Headache Institute, 6114 Fayetteville Rd, Suite 109, Durham, NC, USA

    Alan Finkel

  3. Department of Environmental Health Sciences, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA

    Guoshuai Cai

  4. University of South Carolina School of Medicine, Columbia, SC, 29209, USA

    Alexandra Ross & X. Michelle Androulakis

  5. Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, 29208, USA

    R. Davis Moore

  6. Navy Region Mid-Atlantic, Reserve Component Command, 1683 Gilbert Street, Norfolk, VA, 23511, USA

    Xuesheng Feng

  7. Columbia VA Health Care System, Columbia, SC, 20208, USA

    X. Michelle Androulakis

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  1. Nasim Maleki
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  2. Alan Finkel
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  3. Guoshuai Cai
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  4. Alexandra Ross
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  5. R. Davis Moore
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  6. Xuesheng Feng
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  7. X. Michelle Androulakis
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Correspondence to X. Michelle Androulakis.

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Conflict of Interest

Nasim Maleki, Alan Finkel, Guoshuai Cai, Alexandra Ross, Xuesheng Feng, R. Davis Moore, and X. Michelle Androulakis declare no conflict of interest. X. Michelle Androulakis is supported by a VA grant award # 121RX003194-01A1. Alan Finkel is a Section Editor for Current Pain and Headache Reports. He has not been involved in the review of this paper.

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This article is part of the Topical Collection on Concussion and Head Injury

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Maleki, N., Finkel, A., Cai, G. et al. Post-traumatic Headache and Mild Traumatic Brain Injury: Brain Networks and Connectivity. Curr Pain Headache Rep 25, 20 (2021). https://doi.org/10.1007/s11916-020-00935-y

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