Abstract
Our major objective in this study was to create complex, three-dimensional, and fully transparent polydimethylsiloxane (PDMS) fluidic device by revising the previously reported fabrication process and to systematically study the influence of each fabrication step to the final PDMS fluidic device. The current fabrication process adopted fused deposition modeling (FDM) 3D printers to create molds of acrylonitrile butadiene styrene (ABS) for use in PDMS casting, then solvent solution was used to dissolve the ABS mold embedded inside the PDMS device and a transparent PDMS device was created for experiments. However, it is quite challenging to ensure the complete removal of ABS molds inside the long, curly, and narrow channels. Ultrasonication was added into our fabrication process to improve the efficacy of dissolving ABS molds inside the channels and conclusions can be derived from these experiments: (1) ultrasonication-assisted dissolution is an effective approach to the complete removal of ABS molds embedded inside these long, curly, and narrow channels (for example, the mixer demonstrated herein had a diameter of 2 mm and length of 162 mm); (2) the application of solvent vapor polishing to 3D-printed molds is highly effective in reducing the surface roughness of the molds (8 ~ 10 μm before polishing to 038 ~ 0.5 μm after polishing) and important to preserve the transparency of the resulting PDMS devices; (3) ensuring the circulation of fresh solvent solution is critical to shorten the dissolution process.
Similar content being viewed by others
References
Terry, S.C., Jerman, J.H., Angell, J.B.: A gas chromatographic air analyzer fabricated on a silicon wafer. IEEE Trans. Electron Devices 26(12), 1880–1886 (1979)
Xiang, N., Yi, H., Chen, K., Wang, S., Ni, Z.: Investigation of the maskless lithography technique for the rapid and cost-effective prototyping of microfluidic devices in laboratories. J. Micromech. Microeng. 23(2), 025016 (2013)
He, Y., Fu, J.Z., Chen, Z.C.: Research on optimization of the hot embossing process. J. Micromech. Microeng. 17(12), 2420 (2007)
Attia, U.M., Marson, S., Alcock, J.R.: Micro-injection moulding of polymer microfluidic devices. Microfluid. Nanofluid. 7(1), 1 (2009)
Tay, A., Pavesi, A., Yazdi, S.R., Lim, C.T., Warkiani, M.E.: Advances in microfluidics in combating infectious diseases. Biotechnol. Adv. 34(4), 404–421 (2016)
Zhang, Z., Chen, Y.C., Cheng, Y.H., Luan, Y., Yoon, E.: Microfluidics 3D gel-island chip for single cell isolation and lineage-dependent drug responses study. Lab Chip 16(13), 2504–2512 (2016)
Song, H.H.G., Rumma, R.T., Ozaki, C.K., Edelman, E.R., Chen, C.S.: Vascular tissue engineering: progress, challenges, and clinical promise. Cell Stem Cell 22(3), 340–354 (2018)
Yazdi, A.A., Popma, A., Wong, W., Nguyen, T., Pan, Y., Xu, J.: 3D printing: an emerging tool for novel microfluidics and lab-on-a-chip applications. Microfluid. Nanofluid. 20(3), 50 (2016)
You, B.H., Park, D.S., Rani, S.D., Murphy, M.C.: Assembly of polymer microfluidic components and modules: validating models of passive alignment accuracy. J. Microelectromech. Syst. 24(3), 634–650 (2014)
Anderson, J.R., Chiu, D.T., Jackman, R.J., Cherniavskaya, O., McDonald, J.C., Wu, H., Whitesides, S.H., Whitesides, G.M.: Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. Anal. Chem. 72(14), 3158–3164 (2000)
Luo, Y., Zare, R.N.: Perforated membrane method for fabricating three-dimensional polydimethylsiloxane microfluidic devices. Lab Chip 8(10), 1688–1694 (2008)
Zhang, M., Wu, J., Wang, L., Xiao, K., Wen, W.: A simple method for fabricating multi-layer PDMS structures for 3D microfluidic chips. Lab Chip 10(9), 1199–1203 (2010)
Liao, Y., Song, J., Li, E., Luo, Y., Shen, Y., Chen, D., Cheng, Y., Xu, Z., Sugioka, K., Midorikawa, K.: Rapid prototyping of three-dimensional microfluidic mixers in glass by femtosecond laser direct writing. Lab Chip 12(4), 746–749 (2012)
Jiang, J., Yu, C., Xu, X., Ma, Y., Liu, J.: Achieving better connections between deposited lines in additive manufacturing via machine learning. Math. Biosci. Eng. 17(4), 3382–3394 (2020)
Jiang, J., Lou, J., Hu, G.: Effect of support on printed properties in fused deposition modelling processes. Virtual Phys. Prototyping 14(4), 308–315 (2019)
Gan, X., Wang, J., Wang, Z., Zheng, Z., Lavorgna, M., Ronca, A., Fei, G., Xia, H.: Simultaneous realization of conductive segregation network microstructure and minimal surface porous macrostructure by SLS 3D printing. Mater. Des. 178, 107874 (2019)
Moreno-Rivas, O., Hernández-Velázquez, D., Piazza, V., Marquez, S.: Rapid prototyping of microfluidic devices by SL 3D printing and their biocompatibility study for cell culturing. Mater. Today Proc. 13, 436–445 (2019)
Jiang, J., Weng, F., Gao, S., Stringer, J., Xu, X., Guo, P.: A support interface method for easy part removal in directed energy deposition. Manuf. Lett. 20, 30–33 (2019)
Wittkopf, J.A., Erickson, K., Olumbummo, P., Hartman, A., Tom, H., Zhao, L.: 3D Printed Electronics with Multi Jet Fusion. NIP Digit. Fabric. Conf. 2019(1), 29–33 (2019)
Capel, A.J., Edmondson, S., Christie, S.D., Goodridge, R.D., Bibb, R.J., Thurstans, M.: Design and additive manufacture for flow chemistry. Lab Chip 13(23), 4583–4590 (2013)
Shallan, A.I., Smejkal, P., Corban, M., Guijt, R.M., Breadmore, M.C.: Cost-effective three-dimensional printing of visibly transparent microchips within minutes. Anal. Chem. 86(6), 3124–3130 (2014)
Kang, K., Oh, S., Yi, H., Han, S., Hwang, Y.: Fabrication of truly 3D microfluidic channel using 3D-printed soluble mold. Biomicrofluidics 12(1), 014105 (2018)
Mashiko, T., Otani, K., Kawano, R., Konno, T., Kaneko, N., Ito, Y., Watanabe, E.: Development of three-dimensional hollow elastic model for cerebral aneurysm clipping simulation enabling rapid and low cost prototyping. World Neurosurg. 83(3), 351–361 (2015)
Chatel, G. (2017). Sonochemistry: new opportunities for green chemistry, Acoustic Cavitation, pp. 13–23.
Chen, P., Chiang, C.H.: Taguchi method for investigation of ultrasonication-assisted dissolution of acrylonitrile butadiene styrene (ABS) rod enclosed within polydimethylsiloxane (PDMS) bulk. IEEE Access 8, 114910–114915 (2020)
Acknowledgments
This work was funded by the Ministry of Science and Technology (MOST 108-2221-E-011-144-MY2) and the Mechanical Engineering Department of National Taiwan University of Science and Technology (NTUST).
Author information
Authors and Affiliations
Corresponding author
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Chen, PC., Chou, C.C. & Chiang, C.H. Systematically Studying Dissolution Process of 3D Printed Acrylonitrile Butadiene Styrene (ABS) Mold for Creation of Complex and Fully Transparent Polydimethylsiloxane (PDMS) Fluidic Devices. BioChip J 15, 144–151 (2021). https://doi.org/10.1007/s13206-021-00009-0
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13206-021-00009-0