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Enhancing response time of micro-patterned thermoresponsive hydrogels by incorporation of pores

  • Polymer, Industrial Chemistry
  • Published:
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Abstract

Micro-patterned hydrogels have received increasing attention in various research fields that need a fine structure and advanced functions compared to bulk hydrogels. For enhancing their performance, control of the size and distribution of pores in hydrogels is crucial. In particular, for the application of thermoresponsive hydrogels to a soft actuator, the characteristics of pores play an important role in enhancing the response time. We formed a porous structure in micro-patterns of polydiethylacrylamide (PDEAM), a thermoresponsive hydrogel, and analyzed the effect of pore size on the response time of the patterned hydrogels. Micro-patterned thermoresponsive hydrogels are fabricated by photo-crosslinking PDEAM copolymerized with benzophenone photo-crosslinker and polystyrene (PS) as a porogen. Pores sufficiently smaller than patterned objects, between a few micrometers to a few tens of micrometers, are successfully formed by controlling the content and molecular weight of PS. As the size and number of pores increase, the response time is improved, and the response time for swelling and deswelling is improved by up to 52 and 43% by blending PDEAM with 50 vol% of low molecular weight PS (5 kg/mol). This simple way to form a sub-millimeter scale hydrogel structure with controlled pores can be utilized in the emerging research fields, including 3D cell scaffolds, targeted drug delivery, and soft robotics.

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References

  1. J. L. Ifkovits and J. A. Burdick, Tissue Eng., 13, 2369 (2007).

    Article  CAS  PubMed  Google Scholar 

  2. R. F. Pereira and P. J. Bártolo, Engineering, 1, 90 (2015).

    Article  CAS  Google Scholar 

  3. J. Li and D. J. Mooney, Nat. Rev. Mater, 1, 16071 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. S.-J. Jeon, A. W. Hauser and R. C. Hayward, Acc. Chem. Res., 50, 161 (2017).

    Article  CAS  PubMed  Google Scholar 

  5. T. van Manen, S. Janbaz and A. A. Zadpoor, Mater. Today, 21, 144 (2018).

    Article  CAS  Google Scholar 

  6. O. Erol, A. Pantula, W. Liu and D. H. Gracias, Adv. Mater. Technol., 4, 1900043 (2019).

    Article  CAS  Google Scholar 

  7. B. M. Baker and C. S. Chen, J. Cell Sci., 125, 3015 (2012).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. M. Jamal, S. S. Kadam, R. Xiao, F. Jivan, T.-M. Onn, R. Fernandes, T. D. Nguyen and D. H. Gracias, Adv. Healthcare Mater., 2, 1142 (2013).

    Article  CAS  Google Scholar 

  9. T. S. Shim, S.-H. Kim, C.-J. Heo, H. C. Jeon and S.-M. Yang, Angew. Chem. Int. Ed., 51, 1420 (2012).

    Article  CAS  Google Scholar 

  10. T. G. Leong, C. L. Randall, B. R. Benson, N. Bassik, G. M. Stern and D. H. Gracias, Proc. Natl. Acad. Sci. USA., 106, 703 (2009).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. M. Cianchetti, C. Laschi, A. Menciassi and P. Dario, Nat. Rev. Mater., 3, 143 (2018).

    Article  Google Scholar 

  12. T. Tanaka and D. J. Fillmore, J. Chem. Phys, 70, 1214 (1970).

    Article  Google Scholar 

  13. M. Shibayama and T. Tanaka, Adv. Polym. Sci, 109, 1 (1993).

    Article  CAS  Google Scholar 

  14. X.-Z. Zhang, X.-D. Xu, S.-X. Cheng and R.-X. Zhuo, Soft Matter, 4, 385 (2008).

    Article  CAS  PubMed  Google Scholar 

  15. X.-Z. Zhang, Y.-Y. Yang, T.-S. Chung and K.-X. Ma, Langmuir, 17, 6094 (2001).

    Article  CAS  Google Scholar 

  16. S.-X. Cheng, J.-T. Zhang and R.-X. Zhuo, J. Biomed. Mater. Res. A, 67, 96 (2003).

    Article  PubMed  CAS  Google Scholar 

  17. J.-T. Zhang, S.-X. Cheng and R.-X. Zhuo, J. Polym. Sci., Part A: Polym. Chem, 41, 2390 (2003).

    Article  CAS  Google Scholar 

  18. T. Serizawa, K. Wakita and M. Akashi, Macromolecules, 35, 10 (2002).

    Article  CAS  Google Scholar 

  19. W. Xue, S. Champ, M. B. Huglin and T. G. J. Jones, Eur. Polym. J., 40, 467 (2004).

    Article  CAS  Google Scholar 

  20. J. Grenier, H. Duval, F. Barou, P. Lv, B. David and D. Letourneur, Acta Biomater., 94, 195 (2019).

    Article  CAS  PubMed  Google Scholar 

  21. I. N. Savina, G. C. Ingavle, A. B. Cundy and S. V. Mikhalovsky, Sci. Rep, 6, 21154 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. M. Antonietti, R. A. Caruso, C. G. Göltner and M. C. Weissenberger, Macromolecules, 32, 1383 (1999).

    Article  CAS  Google Scholar 

  23. S. Jiang, F. Liu, A. Lerch, L. Ionov and S. Argawal, Adv. Mater, 27, 4865 (2015).

    Article  CAS  PubMed  Google Scholar 

  24. S. J. Bryant, J. L. Cuy, K. D. Hauch and B. D. Ratner, Biomaterials, 28, 2978 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. S. Wang, L. Li, D. Su, K. Robin and K. A. Brown, ACS Appl. Mater. Interfaces, 10, 34604 (2018).

    Article  CAS  PubMed  Google Scholar 

  26. J. S. Higgins, J. E. G. Lipson and R. P. White, Phil Trans. R. Soc. A, 368, 1009 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. S. Walheim, M. Böltau, J. Mlynek, G. Krausch and U. Steiner, Macromolecules, 30, 4995 (1997).

    Article  CAS  Google Scholar 

  28. S. K. Christensen, M. C. Chiappelli and R. C. Hayward, Macromolecules, 45, 5237 (2012).

    Article  CAS  Google Scholar 

  29. J. Jia, M. Sarker, M. G. Steinmetz, R. Shukla and R. J. Rathore, J. Org. Chem., 73, 8867 (2008).

    Article  CAS  PubMed  Google Scholar 

  30. J. Kim, J. A. Hanna, M. Byun, C. D. Santangelo and R. C. Hayward, Science, 335, 1201 (2012).

    Article  CAS  PubMed  Google Scholar 

  31. J. H. Na, A. A. Evans, J. Bae, M. C. Chiappelli, C. D. Santangelo, R. J. Lang, T. C. Hull and R. C. Hayward, Adv. Mater, 27, 79 (2015).

    Article  CAS  PubMed  Google Scholar 

  32. S.-J. Jeon and R. C. Hayward, Adv. Mater., 29, 1606111 (2017).

    Article  CAS  Google Scholar 

  33. S.-J. Jeon and R. C. Hayward, Soft Matter, 16, 688 (2020).

    Article  CAS  PubMed  Google Scholar 

  34. H. Kojima, Polym. J., 50, 411 (2018).

    Article  CAS  Google Scholar 

  35. S. Bandyopadhyay, A. Sharma, M. A. A. Alvi, R. Raju and W. R. Glomm, RSC Adv., 7, 53192 (2017).

    Article  CAS  Google Scholar 

  36. H. Guo, J. Cheng, J. Wang, P. Huang, Y. Liu, Z. Jia, X. Chen, K. Sui, T. Li and Z. Nie, J. Mater. Chem. B, 5, 2883 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. B. Ziółkowski, L. Florea, J. Theobald, F. Benito-Lopez and D. Diamond, J. Mater. Sci, 51, 1392 (2016).

    Article  CAS  Google Scholar 

  38. J. Yi, G. Choe, J. Park and J. Y. Lee, Polym. J., 52, 823 (2020).

    Article  CAS  Google Scholar 

  39. L. E. Beckett, J. T. Lewis, T. K. Tonge and L. T. J. Korley, ACS Biomater. Sci. Eng., 6, 5453 (2020).

    Article  CAS  PubMed  Google Scholar 

  40. E. C. Dragan, Chem. Eng. J., 243, 572 (2014).

    Article  CAS  Google Scholar 

  41. J. P. Gong, Soft Matter, 6, 2583 (2010).

    Article  CAS  Google Scholar 

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Acknowledgement

This work was supported by Kumoh National Institute of Technology (2018-104-145).

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, Kumoh National Institute of Technology, Gumi, Gyeongbuk, 39177, Korea

    Si-Eun Park & Seog-Jin Jeon

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  1. Si-Eun Park
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  2. Seog-Jin Jeon
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Correspondence to Seog-Jin Jeon.

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The authors declare no competing financial interest.

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Park, SE., Jeon, SJ. Enhancing response time of micro-patterned thermoresponsive hydrogels by incorporation of pores. Korean J. Chem. Eng. 38, 645–651 (2021). https://doi.org/10.1007/s11814-020-0711-2

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  • DOI: https://doi.org/10.1007/s11814-020-0711-2

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