Skip to main content

Advertisement

Log in

Bednets or Biotechnology: To Rescue Current Persons or Research for the Future?

  • Original Paper
  • Published:
Fudan Journal of the Humanities and Social Sciences Aims and scope Submit manuscript

Abstract

Malaria is still a significant cause of death and suffering throughout much of the developing world. Fortunately, the global community provides significant (though, not sufficient) resources to combat the disease and the parasite that causes it. How ought we to allocate these resources? One option is to purchase and distribute perhaps the best tool we have to prevent malaria: insecticide-treated nets. Another route would see us invest in research and development of a novel biotechnology that could eradicate the disease in perpetuity. If we choose to spend our money on insecticide-treated nets, we will be rescuing current individuals at risk of being infected with the parasite. Though, we can be almost certain there will be future individuals who will also need rescuing. If we instead invest in the novel biotechnology, we could benefit countless future individuals who never have to experience the threat of malaria. Hence, this would mean that some number of current individuals will die due to the lack of insecticide-treated nets that otherwise could have saved their lives. So, ought we to rescue current, identifiable individuals, or ought we invest in research for the sake of the future? After an exploration of the duty to rescue and cost-effectiveness analysis, I suggest we look towards the literature on intergenerational justice for a justifiable answer to the question of how we ought to allocate our malaria resources.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Notes

  1. ITNs also generate significant corollary benefits.

  2. It could also have other significant co-benefits. For instance, gene drives could: help eradicate other vector-borne diseases (such as zika, dengue, chikungunya, and others); could help control invasive species and preserve biodiversity; and could increase crop yields. Some of the research done on gene drive solutions to malaria could help develop the technology in these other areas as well.

  3. I should note that while my focus will be on the specific case malaria, the discussion generalizes to many different kinds of decisions.

  4. I should note that the WHO’s estimates are lower than other estimates. For instance, the Institute of Health Metrics and Evaluation has released estimates that are nearly double that of the WHO. See (World Health Organization 2018a, 37).

  5. There is a new vaccine that will begin pilot introduction in 2019. See: (World Health Organization 2018b).

  6. Of course, it is possible to eliminate malaria with the traditional methods. This has been accomplished and in many parts of the world. But, for the reasons I cite below, relying exclusively upon traditional methods for the complete elimination of malaria would be difficult.

  7. Of course, the population has increased significantly even in this short time span, especially in the developing where world malaria is endemic. So, some of this parity is slightly misleading.

  8. Only female mosquitoes bite and thus only female mosquitoes are vectors for malaria.

  9. This kind of dilemma is similar to the one described by Johann Frick with respect to HIV/AIDS treatment and prevention. See: (Frick 2015).

  10. For the canonical article, see: (Jonsen 1986). For further specification of the rule of rescue, see: (McKie and Richardson 2003).

  11. The duty to rescue is also similar to what Rawls called “the duty to assist.” Though, Rawls’ duty applies to state institutions as opposed to individuals. See: (Rawls 2002, 106).

  12. For an attempt to institutionalize the duty, see: (Rulli and Millum 2016).

  13. Such a requirement has been criticized as being “overdemanding.” For a critical discussion of such an objection, Cf. (Sonderholm 2013).

  14. For instance, it was estimated that ITNs cost roughly $5 to $17 per QALY produced. See: (Jamison and World Bank 2006, 45).

  15. To see just how thorny this debate is, see the dramatically different recommendations generated by Sir Nicholas Stern and William Nordhaus with respect to climate change—recommendations that diverge due to reliance upon different discount rates. Cf. (Nordhaus 1994) and (Stern 2007).

  16. Though, it may not need to be one of scarcity. I’ll say something about this in the conclusion.

  17. And, for Rawls, to say that the basic structure is just is to say that it abides by the two principles of justice (as constrained by the just savings principle). See: (Rawls 1999, 266).

  18. This is similar to (yet different from) the discussion had by Brock and Wikler on permanent and temporary scarcity. See: (Brock and Wikler 2009).

  19. For a discussion about how difficult decisions like the one being explored can lead to changes in funding, see: (Beauchamp and Childress 2013, 280).

References

  • Beauchamp, Tom L., and James F. Childress. 2013. Principles of Biomedical Ethics, 7th ed. New York: Oxford University Press.

    Google Scholar 

  • Bhatt, S., D.J. Weiss, E. Cameron, D. Bisanzio, B. Mappin, U. Dalrymple, K.E. Battle, et al. 2015. The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015. Nature 526: 207–211. https://doi.org/10.1038/nature15535.

    Article  Google Scholar 

  • Brock, Dan W., and Daniel Wikler. 2009. Ethical challenges in long-term funding for HIV/AIDS. Health Affairs 28: 1666–1676. https://doi.org/10.1377/hlthaff.28.6.1666.

    Article  Google Scholar 

  • Buchanan, Allen. 2003. Justice, Legitimacy, and Self-Determination. Oxford: Oxford University Press.

    Book  Google Scholar 

  • Frick, Johann. 2015. Treatment versus prevention in the fight against HIV/AIDS and the problem of identified versus statistical lives. In Identified Versus Statistical Lives, ed. I.Glenn Cohen, Norman Daniels, and Nir Eyal, 182–202. Oxford: Oxford University Press. https://doi.org/10.1093/acprof:oso/9780190217471.003.0014.

    Chapter  Google Scholar 

  • Gantz, Valentino M., and Ethan Bier. 2016. The dawn of active genetics. BioEssays 38: 50–63. https://doi.org/10.1002/bies.201500102.

    Article  Google Scholar 

  • Gantz, Valentino M., Nijole Jasinskiene, Olga Tatarenkova, Aniko Fazekas, Vanessa M. Macias, Ethan Bier, and Anthony A. James. 2015. Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi. Proceedings of the National Academy of Sciences 112: E6736–E6743. https://doi.org/10.1073/pnas.1521077112.

    Article  Google Scholar 

  • Hammond, Andrew, Roberto Galizi, Kyros Kyrou, Alekos Simoni, Carla Siniscalchi, Dimitris Katsanos, Matthew Gribble, et al. 2016. A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae. Nature Biotechnology 34: 78–83. https://doi.org/10.1038/nbt.3439.

    Article  Google Scholar 

  • Hoffmann-Riem, Holger, and Brian Wynne. 2002. In risk assessment, one has to admit ignorance. Nature 416: 123.

    Article  Google Scholar 

  • Intergovernmental Panel on Climate Change. 2018. IPCC, 2018: Summary for Policymakers. In: Global Warming of 1.5 C, an IPCC special report on the impacts of global warming of 1.5 C above pre-industrial levels and related global greenhouse gas emission pathways, in the context of strengthening the global response to the threat of climate change, sustainable development, and efforts to eradicate poverty. Cambridge, UK & New York: Cambridge University Press.

  • Jamison, Dean T., and World Bank (eds.). 2006. Disease Control Priorities in Developing Countries, 2nd ed. Washington, DC: World Bank.

    Google Scholar 

  • Jonsen, Albert. 1986. Bentham in a box: Technology assessment and health care allocation. Law, Medicine and Health Care 14: 172–174.

    Article  Google Scholar 

  • Keeler, Emmett B., and Shan Cretin. 1983. Discounting of life-saving and other nonmonetary effects. Management Science 29: 300–306. https://doi.org/10.1287/mnsc.29.3.300.

    Article  Google Scholar 

  • Kyrou, Kyros, Andrew M. Hammond, Roberto Galizi, Nace Kranjc, Austin Burt, Andrea K. Beaghton, Tony Nolan, and Andrea Crisanti. 2018. A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes. Nature Biotechnology 36: 1062–1066. https://doi.org/10.1038/nbt.4245.

    Article  Google Scholar 

  • McKie, John, and Jeff Richardson. 2003. The rule of rescue. Social Science and Medicine 56: 2407–2419. https://doi.org/10.1016/S0277-9536(02)00244-7.

    Article  Google Scholar 

  • National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: National Academies Press. https://doi.org/10.17226/23405.

    Book  Google Scholar 

  • Nord, Erik, Jeff Richardson, Andrew Street, Helga Kuhse, and Peter Singer. 1995. Maximizing health benefits vs egalitarianism: An Australian survey of health issues. Social Science and Medicine 41: 1429–1437. https://doi.org/10.1016/0277-9536(95)00121-M.

    Article  Google Scholar 

  • Nordhaus, William D. 1994. Managing the Global Commons: The Economics of Climate Change. Cambridge: MIT Press.

    Google Scholar 

  • Rawls, John. 1999. A Theory of Justice. Cambridge: Harvard University Press.

    Google Scholar 

  • Rawls, John. 2002. The Law of Peoples. [Place of publication not identified]: Harvard University Press.

  • Rawls, John. 2005. Political Liberalism. New York: Columbia University Press.

    Google Scholar 

  • Rulli, Tina, and Joseph Millum. 2016. Rescuing the duty to rescue. Journal of Medical Ethics 42: 260–264. https://doi.org/10.1136/medethics-2013-101643.

    Article  Google Scholar 

  • Singer, Peter. 1972. Famine, affluence, and morality. Philosophy & Public Affairs 1: 229–243.

    Google Scholar 

  • Smith, Patricia. 1990. The duty to rescue and the slippery slope problem. Social Theory and Practice 16: 19–41.

    Article  Google Scholar 

  • Sonderholm, Jorn. 2013. World poverty, positive duties, and the overdemandingness objection. Politics, Philosophy and Economics 12: 308–327. https://doi.org/10.1177/1470594X12447779.

    Article  Google Scholar 

  • Stern, Nicholas. 2007. The Economics of Climate Change: The Stern Review. Edited by Great Britain. Cambridge, UK ; New York: Cambridge University Press.

  • White, Nicholas J. 2004. Antimalarial drug resistance. Journal of Clinical Investigation 113: 1084–1092. https://doi.org/10.1172/JCI21682.

    Article  Google Scholar 

  • World Health Organization. 2017. World Malaria Report 2017. Geneva: World Health Organization.

    Book  Google Scholar 

  • World Health Organization. 2018a. World Malaria Report 2018. Geneva: World Health Organization.

    Book  Google Scholar 

  • World Health Organization. 2018b. First Malaria Vaccine in Africa: A Potential New Tool for Child Health and Improved Malaria Control. Geneva: World Health Organization.

    Google Scholar 

  • World Health Organization, and Global Malaria Programme. 2015. Global Technical Strategy for Malaria, 2016–2030. Geneva: World Health Organization.

    Google Scholar 

Download references

Acknowledgements

For helpful comments and discussion, I’d like to thank Amy Zhou, John Evans, Craig Callender, Reuven Brandt, Christopher Preston, Theron Pummer, Kian Mintz-Woo, Richard Arneson, and the participants of the International Society for Environmental Ethics’ special session at the 2019 American Philosophical Association’s Pacific Division meeting, the participants of the “Global Justice” workshop at Fudan University, as well as the participants of UCSD’s First Annual Gene Drive Conference.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Daniel Edward Callies.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Callies, D.E. Bednets or Biotechnology: To Rescue Current Persons or Research for the Future?. Fudan J. Hum. Soc. Sci. 13, 559–572 (2020). https://doi.org/10.1007/s40647-020-00290-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s40647-020-00290-7

Keywords

Navigation