Abstract
The effects of ΔPb-CATH4, a cathelicidin derived from Python bivittatus, were evaluated against Staphylococcus aureus-infected wounds in mice. These effects were comparable to those of classical antibiotics. ΔPb-CATH4 was resistant to bacterial protease but not to porcine trypsin. A reduction in the level of inflammatory cytokines and an increase in the migration of immune cells was observed in vitro. Thus, ΔPb-CATH4 can promote wound healing by controlling infections including those caused by multidrug-resistant bacteria via its immunomodulatory effects.
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Acknowledgements
This work was supported by Basic Science Research Program through the National Research Future Planning (No. 2015R1A5A1009701), Republic of Korea, and Konkuk University Researcher Fund in 2019.
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The authors declare competing financial interests. The peptide sequences of ΔPb-CATH4 are subject to domestic and foreign patent applications by Konkuk University.
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The experimental protocols and animal care were approved and supervised by the Institute of Animal Care and Use Committee of Konkuk University, Seoul, Korea (KU15119).
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Nagasundarapandian, S., Cho, Hs., Prathap, S. et al. Cathelicidin ΔPb-CATH4 derived from Python bivittatus accelerates the healing of Staphylococcus aureus-infected wounds in mice. Amino Acids 53, 313–317 (2021). https://doi.org/10.1007/s00726-021-02948-2
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DOI: https://doi.org/10.1007/s00726-021-02948-2