Research ArticleSCO-spondin-derived Peptide Protects Neurons from Glutamate-induced Excitotoxicity
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Abbreviations
Aβ
amyloid β
AIF1
apoptosis-inducing factor 1
Akt
protein kinase B
ANOVA
analysis of variance
APP
amyloid precursor protein
Bax
B-cell lymphoma 2-associated X
Bcl-2
B-cell lymphoma 2
BDNF
brain-derived neurotrophic factor
BSA
bovine albumin serum
Cyt c
cytochrome c
dpi
days post-injury
div
days in vitro
DNA
deoxyribonucleic acid
ECM
extracellular matrix
FCS
fetal calf serum
FTS
farnesylthiosalicyclic acid
glu
glutamate
GMP
good manufacturing practices
LDH
lactate dehydrogenase
KW
Kruskal–Wallis
l-NAME
l-NG-nitroarginine methyl ester
MAPK
mitogen-activated protein kinase
MAP-2
microtubule associated protein-2
MEK
mitogen-activated protein/extracellular signal-regulated kinase kinase
mTOR
mammalian target of rapamycin
NADH
nicotinamide adenine dinucleotide hydrogen
NCID
Notch intracellular domain
NFκB
nuclear factor-kappa B
NOS
nitric oxide synthase
NMdA
N-methyl-d-aspartate
PBS
phosphate buffered saline
PI3K
phosphoinositide 3-kinase
PS
penicillin/streptomycin
p70S6K
ribosomal protein S6 kinase
Ras
rat sarcoma
RT
room temperature
SCO
subcommissural organ
SEM
standard error of the mean
TrkB
tropomyosin receptor kinase B
TSR
thrombospondin repeat
Tuj1
neuron-specific class III beta-tubulin
Key words
NX210
NX210c
β1-integrin
γ-secretase
PI3K/mTOR
Bcl-2
Cited by (0)
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These authors contributed equally to this work.
© 2021 The Author(s). Published by Elsevier Ltd on behalf of IBRO.