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Microbial-derived antigens and metabolites in spondyloarthritis

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Abstract

Spondyloarthritis (SpA) is a group of chronic, immune-mediated, inflammatory diseases affecting the bone, synovium, and enthesis. Microbiome, the community of microorganisms that has co-evolved with human hosts, plays a pivotal role in human health and disease. This invisible “essential organ” supplies the host with a myriad of chemicals and molecules. In turn, microbial metabolites can serve as messengers for microbes to communicate with each other and in the cross-talk with host cells. Gut dysbiosis in SpA is associated with altered microbial metabolites, and an accumulated body of research has contributed to the understanding that changes in intestinal microbiota can modulate disease pathogenesis. We review the novel findings from human and animal studies to provide an overview of the contribution of individual microbial metabolites and antigens to SpA.

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Funding

Work in the Koralov and Scher laboratories was supported by joint grants from the Judith and Stewart Colton Center for Autoimmunity and NPF Psoriatic Arthritis Diagnostic Test Grant. Research in the Koralov laboratory is further supported by NIH R01HL125816, funding from Drs. Martin and Dorothy Spatz Foundation, LEO Foundation (LF-OC-20-000351), and the Irma T. Hirschl and Monique Weill-Caulier Trust. Work in the Chang Lab is supported by NIH R01AR070131 and R01AR073851 grants. Research in the Scher laboratory is further supported by NIH/NIAMS R01AR074500, the Snyder Family Foundation, and the Riley Family Foundation.

Author information

Authors and Affiliations

  1. Department of Pathology, NYU School of Medicine, 522 First Ave. Smilow Research Bldg 511, New York, NY, 10016, USA

    Katharine Lu Yang, Alannah Lejeune & Sergei B. Koralov

  2. Department of Radiology, NYU School of Medicine, New York, NY, 10016, USA

    Gregory Chang

  3. Division of Rheumatology, Department of Medicine, NYU School of Medicine, New York, NY, 10016, USA

    Jose U. Scher

  4. Division of Rheumatology and Psoriatic Arthritis Center, 301 East 17th St, Room 1608, New York, NY, 10003, USA

    Jose U. Scher

Authors
  1. Katharine Lu Yang
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  2. Alannah Lejeune
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  3. Gregory Chang
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  4. Jose U. Scher
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  5. Sergei B. Koralov
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Corresponding authors

Correspondence to Jose U. Scher or Sergei B. Koralov.

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Conflict of interest

Drs. Scher and Koralov are co-authors on US Patent 10,226,443 “Methods for treating psoriatic arthritis.” The other authors declare no competing interests.

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This article is a contribution to the Special issue on: Spondyloarthritis - Guest Editors: Robert Inman & Nigil Haroon

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Yang, K.L., Lejeune, A., Chang, G. et al. Microbial-derived antigens and metabolites in spondyloarthritis. Semin Immunopathol 43, 163–172 (2021). https://doi.org/10.1007/s00281-021-00844-1

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  • DOI: https://doi.org/10.1007/s00281-021-00844-1

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