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Reactions of 1-benzoyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzodiazepine with alicyclic Reformatsky reagents

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Chemistry of Heterocyclic Compounds Aims and scope

The reactions of 1-benzoyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzodiazepine with methyl 1-bromocycloalkanecarboxylates and zinc, followed by hydrolysis of the reaction mixtures, resulted in the formation of spiro-δ-lactams bearing a 2-(N-benzoylamino)phenyl substituent at the nitrogen atom. The product structures were confirmed by X-ray structural analysis, and a mechanism was proposed for the product formation.

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Correspondence to Elena A. Nikiforova.

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Translated from Khimiya Geterotsiklicheskikh Soedinenii, 2021, 57(1), 92–94

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Nikiforova, E.A., Zverev, D.P., Dmitriev, M.V. et al. Reactions of 1-benzoyl-2,4-diphenyl-2,3-dihydro-1H-1,5-benzodiazepine with alicyclic Reformatsky reagents. Chem Heterocycl Comp 57, 92–94 (2021). https://doi.org/10.1007/s10593-021-02872-z

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  • DOI: https://doi.org/10.1007/s10593-021-02872-z

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