Acetaminophen metabolism revisited using non-targeted analyses: Implications for human biomonitoring
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Abbreviations
APAP
acetaminophen
APAP-S
APAP sulfate
APAP-Glu
APAP glucuronide
NAPQI
N-acetyl-p-benzoquinone imine
3-OH-APAP
3-hydroxyacetaminophen
3-OH-APAP-S
3-hydroxyacetaminophen sulfate
3-OCH3-APAP
3-methoxyacetaminophen
3-OCH3-APAP-Glu
3-methoxyacetaminophen glucuronide
APAP-SG
acetaminophen glutathione
APAP-Cys
3-(Cystein-S-yl)acetaminophen
NAC-APAP
Acetaminophen mercapturate
NAC-O-APAP
Acetaminophen mercapturate sulfoxide
SH-APAP
3-mercaptoacetaminophen
SH-APAP-Glu
3-mercaptoacetaminophen glucuronide
SH-APAP-S
3-mercaptoacetaminophen sulfate
S-CH3-APAP
S-methyl-3-thioacetaminophen
S-CH3-APAP-S
S-methyl-3-thioacetaminophen sulfate
S-CH3-APAP-Glu, SO-CH3-APAP-Glu
S-methyl-3-thioacetaminophen glucuronide
SO-CH3-APAP
S-methyl-3-thioacetaminophen sulphoxide
SO-CH3-APAP-S
S-methyl-3-thioacetaminophen sulphoxide sulphate
Keywords
Paracetamol/acetaminophen
Human biomonitoring
Non-targeted analyses
High-resolution mass spectrometry (HRMS)
Cited by (0)
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Joint last authors.
© 2021 The Author(s). Published by Elsevier Ltd.