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Relationship between Pro- and Antioxidant Status and Cytokine Profile in Piglets under Technological Stress

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Abstract

The study outcomes of dynamic parameters for the pro- and anitoxidant status and the cytokine profile in piglets under the stress caused by weaning them from sows for their transfer to growing-fattening facilities under conditions of an industrial-sized pig farm are reported. It has been ascertained that the technological stress affecting the animals is followed by increasing the contents of malondialdehyde and medium molecular-weight peptides, the endogenous intoxication, and the level of proinflammatory cytokines on days 3–10 after the stress effect. Increasing the antioxidant-defense enzyme activity and the levels of stable nitric-oxide metabolites and IL-4 and IL-10 anti-inflammatory cytokines contributed to normalizing the body’s metabolic processes and decreasing the contents of IL-1β, TNF-α, and IFN-γ anti-inflammatory cytokines. The dynamics of variations in the pro- and anitoxidant status and the cytokine profile can indicate their interdependence under the oxidative stress associated with the events of weaning and transferring them to growing-fattening facilities. The process of adaptation to the new conditions was usually completed on the 20th day after the stress effect. In addition, most analyzed parameters were restored to the preweaning levels.

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Authors and Affiliations

  1. All-Russia Research Veterinary Institute of Pathology, Pharmacology, and Therapy, 394087, Voronezh, Russia

    S. V. Shabunin, A.G. Shakhov, L. Yu. Sashnina, G. A. Vostroilova, T. G. Ermolova & Yu. Yu. Vladimirova

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  1. S. V. Shabunin
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  2. A.G. Shakhov
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  3. L. Yu. Sashnina
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  4. G. A. Vostroilova
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  5. T. G. Ermolova
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  6. Yu. Yu. Vladimirova
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Corresponding author

Correspondence to G. A. Vostroilova.

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Conflict of interest. The authors declare that they have no conflict of interests.

Statement of welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. The article does not concern any researches using animals as objects.

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Translated by O. Zhiryakova

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Shabunin, S.V., Shakhov, A., Sashnina, L.Y. et al. Relationship between Pro- and Antioxidant Status and Cytokine Profile in Piglets under Technological Stress. Russ. Agricult. Sci. 46, 623–627 (2020). https://doi.org/10.3103/S1068367420060178

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  • DOI: https://doi.org/10.3103/S1068367420060178

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