Abstract
The ion-sensitive field effect transistor (ISFET) is a promising tool for detecting intermolecular interactions, including biochemical ones. Using the ISFET, it is possible to recognize various mechanisms of specifically adsorbed substances. In addition, ISFET can be integrated with CMOS technology, which opens up new prospects for creating intelligent micro- and nanosystems. In this study, the influence of the design and technological parameters of the ISFET on charge sensitivity is investigated using numerical simulation. Two types of the ISFET design based on a completely depleted floating-gate SOI structure are presented. The designs differ by the way of forming the liquid medium–gate contact. The analytical dependences of the charge sensitivity of the ISFET, which make it possible to analyze the ISFET sensitivity, are obtained. It is shown that the limiting sensitivity is achievable on a composite nanowire structure with submicron dimensions. The sensitivity of the considered ISFET design with the characteristic size of 1.2 µm when an analyte is adsorbed is about 50 effective electron charges. The ISFET designed with submicron physical dimensions (wire width of 10 nm and wire length of 100 nm) has the sensitivity of 1 to 2 effective electron charges.
Similar content being viewed by others
REFERENCES
Wasilewski, T., Gębicki, J., and Kamysz, W., Bioelectronic nose: current status and perspectives, Biosens. Bioelectron., 2017, vol. 87, pp. 480–494.
Fitzgerald, J. and Fenniri, H., Cutting edge methods for non-invasive disease diagnosis using e-tongue and e-nose devices, Biosensors, 2017, vol. 7, pp. 59–65.
Bergveld, P., Development of an ion-sensitive solid-state device for neurophysiological measurements, IEEE Trans. Biomed. Eng., 1970, vol. 17, pp. 70–71.
Matsuo, T. and Esashi, M., Methods of ISFET fabrication, Sens. Actuators, 1981, vol. 1, pp. 77–96.
Cui, Y., Wei, O., Pork, H., and Lieber, C., Nanowire nanosensors for highly sensitive and selective detection of biological and chemical species, Science (Washington, DC, U. S.), 2001, vol. 293, pp. 1289–1292.
Kuznetsov, E.V. and Chuyko, O.V., Study of the sensitivity of pH-sensors based on silicon MOS-nanotransistors, Russ. Microelectron., 2014, vol. 43, no. 7, pp. 511–515.
Schneider, M.C. and Galup-Montoro, C., CMOS Analog Design Using All-Region MOSFET Modeling, Cambridge: Cambridge Univ. Press, 2010.
Van Hal, R.E.G., Eijkel, J.C.T., and Bergveld, P., A general model to describe the electrostatic potential at electrolyte oxide interfaces, Adv. Colloid Interface Sci., 1996, vol. 69, no. 1, pp. 31–62.
Poghossian, A.S., The super-nernstian pH sensitivity of Ta2O5-gate ISFETs, Sens. Actuators, B, 1992, vol. 7, no. 1, pp. 367–370.
Sze, S.M. and Kwok, K.Ng., Physics of Semiconductor Devices, Chichester: Wiley, 2006.
Colinge, J.P., FinFETs and Other Multi-Gate Transistors, New York: Springer, 2008.
Arora, N., MOSFET Modeling for VLSI Simulation: Theory and Practice, Singapore: World Scientific, 2007.
Kuznetsov, A., Komarova, N., Andrianova, M., et al., Aptamer based vanillin sensor using an ion-sensitive field-effect transistor, Microchim. Acta, 2018, vol. 185, no. 1, pp. 3–11.
Funding
The work was financially supported by the Russian Foundation for Basic Research (project no. 18-34-20020).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated by Z. Smirnova
Rights and permissions
About this article
Cite this article
Gubanova, O.V., Kuznetsov, E.V., Rybachek, E.N. et al. Biosensor Based on Ion-Sensitive Nanowire Field-Effect Transistor Using the Minimum Contact to the Floating Gate. Russ Microelectron 49, 538–542 (2020). https://doi.org/10.1134/S1063739720070045
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1063739720070045