Abstract
MnFe2O4 nanoparticles are used in medicine for cancer treatments through hyperthermia, gene, and drug delivery systems. The primary purpose of the current investigation was to study the effect of the MnFe2O4 nanoparticles on the structure and function of acid phosphatase. The enzyme activity displayed that MnFe2O4 nanoparticles acted as a non-competitive inhibitor. Ki was calculated to be 0.217 mM. The thermal denaturation analysis also demonstrated that Tm was decreased by adding MnFe2O4 nanoparticles concentrations (from 342.0–338.5 K). Far-UV circular studies also revealed that MnFe2O4 nanoparticles could alter the secondary structure of acid phosphatase by the enhancement of the \(\alpha\)-helix contents (from 10.8 to 11.3%) and the decrease of the \(\beta\)-sheet (from 30.2 to 29.8%). It was also shown that MnFe2O4 nanoparticles decreased the intrinsic fluorescence of acid phosphatase via the static quenching. Also, with the rise of temperature, the Stern–Volmer constant was declined from 9.95 \(\times {10}^{4}\) to 2.42 M\(\times {10}^{4}\)−1. The hydrogen bonding and van der Waals interactions also played a significant role in this interaction. These results also showed that MnFe2O4 nanoparticles changed the conformational of acid phosphatase. Overall, MnFe2O4 nanoparticles could influence the activity and stability of acid phosphatase.
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Kim J, Grate JW, Wang P (2006) Chem Eng Sci 61:1017
Momeni L, Shareghi B, Saboury A, Evini M (2017) Monatsh Chem 148:199
Bohlooli M, Moosavi-Movahedi A, Taghavi F, Maghami P, Saboury A, Moosavi-Movahedi Z, Farhadi M, Hong J, Sheibani N, Habibi-Rezaei M (2013) Int J Biol Macromol 62:358
Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE (2001) J Control Release 70:1
Panyam J, Labhasetwar V (2003) Adv Drug Deliv Rev 55:329
Shareghi B, Farhadian S, Zamani N, Salavati-Niasari M, Gholamrezaei S (2016) Monatsh Chem 147:465
Beji Z, Hanini A, Smiri L, Gavard J, Kacem K, Villain F, Greneche J-M, Chau F, Ammar S (2010) Chem Mater 22:5420
Pradhan P, Giri J, Samanta G, Sarma HD, Mishra KP, Bellare J, Banerjee R, Bahadur D (2007) J Biomed Mater Res B Appl Biomater 81:12
Liang H, Wang Z (2010) Mater Chem Phys 124:964
Chakraborty I, Majumder D, Talukdar S, Roy S, Mandal K (2017) Surf Interfaces 9:154
Kanagesan S, Aziz SBA, Hashim M, Ismail I, Tamilselvan S, Alitheen NBBM, Swamy MK, Purna Chandra Rao B (2016) Molecules 21:312
Sen S, Konar S, Pathak A, Dasgupta S, DasGupta S (2014) J Phys 118:11667
Matzen S, Moussy J-B, Mattana R, Bouzehouane K, Deranlot C, Petroff F, Cezar J, Arrio M-A, Sainctavit P, Gatel C (2011) Phys Rev B 83:184402
Zhang Y, Kohler N, Zhang M (2002) Biomaterials 23:1553
Lu J, Ma S, Sun J, Xia C, Liu C, Wang Z, Zhao X, Gao F, Gong Q, Song B (2009) Biomaterials 30:2919
Wang Y, Cheng R, Wen Z, Zhao L (2011) Eur J Inorg Chem 19:2942
Liu C, Zou B, Rondinone AJ, Zhang ZJ (2000) J Phys 104:1141
Grancharov SG, Zeng H, Sun S, Wang SX, O’Brien S, Murray C, Kirtley J, Held G (2005) J Phys 109:13030
Huong PTL, Phan VN, Huy TQ, Nam MH, Lam VD, Le A-T (2016) J Electron Mater 45:2372
Mahdavian AR, Mirrahimi MAS (2010) Chem Eng 159:264
Wei Y, Li Y, Liu X, Xian Y, Shi G, Jin L (2010) Biosens Bioelectron 26:275
Wang S, Zhou Y, Yang S, Ding B (2008) Colloid Surf B 67:122
Cedervall T, Lynch I, Lindman S, Berggård T, Thulin E, Nilsson H, Dawson KA, Linse S (2007) Proc Natl Acad Sci USA 104:2050
Lynch I, Cedervall T, Lundqvist M, Cabaleiro-Lago C, Linse S, Dawson KA (2007) Adv Colloid Interface Sci 134:167
Durmus A, Eicken C, Horst Sift B, Kratel A, Kappl R, Hüttermann J, Krebs B (1999) Eur J Biochem 260:709
Bozzo GG, Raghothama KG, Plaxton WC (2004) Biochem J 377:419
Moradi S, Shareghi B, Saboury AA, Farhadian S (2020) Int J Biol Macromol 150:90
Schenk G, Boutchard CL, Carrington LE, Noble CJ, Moubaraki B, Murray KS, De Jersey J, Hanson GR, Hamilton S (2001) J Biol 276:19084
Bull H, Murray PG, Thomas D, Fraser A, Nelson PN (2002) Mol Pathol 55:65
Flood P, Tyler N, Read E, Rodway M, Chedrese P (2005) Anim Reprod Sci 85:147
Imai K, Khandoker M, Yonai M, Takahashi T, Sato T, Ito A, Hasegawa Y, Hashizume K (2003) Domest Anim Endocrinol 24:171
Farhadian S, Shareghi B, Saboury AA, Babaheydari AK, Raisi F (2016) Int J Biol Macromol 92:523
Moradi S, Shareghi B, Saboury AA (2020) Monatsh Chem 151:637
Meti MD, Nandibewoor ST, Joshi SD, More UA, Chimatadar SA (2016) J Iran Chem Soc 13:1325
Hosseini-Koupaei M, Shareghi B, Saboury AA, Davar F (2017) Int J Biol Macromol 94:406
Zhao X, Hao F, Lu D, Liu W, Zhou Q, Jiang G (2015) ACS Appl Mater 7:18880
Pasban Ziyarat F, Asoodeh A, Sharif Barfeh Z, Pirouzi M, Chamani J (2014) J Biomol Struct Dyn 32:613
Momeni L, Shareghi B, Saboury AA, Farhadian S (2016) J Phys 120:9632
Paul BK, Guchhait N (2011) Photochem Photobiol Sci 10:980
Li D, Ji B, Jin J (2008) J Lumin 128:1399
Saeidifar M, Mansouri-Torshizi H, Saboury AA (2015) J Lumin 167:391
Ross P, Subramanian S (1981) Biochemistry 20:3096
Sugiura Y, Kawabe H, Tanaka H, Fujimoto S, Ohara A (1981) Int J Biol Chem 256:10664
Momeni L, Shareghi B, Saboury AA (2017) J Biomol Struct Dyn 35:1381
Starikov EB (2011) arXiv preprint arXiv:11106352
Starikov EB (2013) Monatsh Chem 144:97
Starikov EB, Nordén B (2012) Chem Phys Lett 538:118
Starikov EB, Nordén B (2012) Appl Phys Lett 100:193701
Chen Q-X, Zhang R-Q, Yang P-Z, Li Y, Chen S-L, Li S, Yang Y, Zhou H-M (1999) Int J Biol Macromol 26:103
Saboury A (2009) J Iran Chem Soc 6:219
Saboury A, Divsalar A, Ataie G, Amanlou M, Moosavi-Movahedi A, Hakimelahi G (2003) Acta Biochim Pol 50:849
Kelly SM, Jess TJ, Price NC (2005) Biochim Biophys Acta Proteins Proteom 1751:119
Divsalar A, Saboury AA, Haertlé T, Sawyer L, Mansouri-Torshizi H, Barzegar L (2013) J Solution Chem 42:705
Babaknejad N, Shareghi B, Saboury AA (2019) Spectrosc Lett 52:81
Lees JG, Miles AJ, Wien F, Wallace B (2006) J Bioinform 22:1955
Manavalan P, Johnson WC (1983) Nature 305:831
Treuel L, Malissek M (2013) Cellular and Subcellular Nanotechnology. Springer, p 225
Gagner JE, Lopez MD, Dordick JS, Siegel RW (2011) Biomaterials 32:7241
Pal M, Rakshit R, Mandal K (2014) ACS Appl Mater Inter 6:4903
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Authors are grateful to the council of the University of Shahrekord for providing the financial support.
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Moradi, S., Shareghi, B., Saboury, A.A. et al. Evaluation of the effect of MnFe2O4 nanoparticles on the activity parameters and stability of acid phosphatase. Monatsh Chem 152, 175–184 (2021). https://doi.org/10.1007/s00706-020-02728-w
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DOI: https://doi.org/10.1007/s00706-020-02728-w