Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides

Boris Shavkuta; Kseniia Bardakova; Yana Khristidis; Nikita V. Minaev; Anastasia Frolova; Svetlana Kotova; Nadezhda Aksenova; Zahra Heydari; Elena Semenova; Tatyana Khlebnikova; Elena N. Golubeva; Sergei Kostjuk; Massoud Vosough; Peter S. Timashev; Anastasia I. Shpichka

doi:10.1039/D0ME00157K

Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides

Boris Shavkuta,^ab Kseniia Bardakova,

^ac Yana Khristidis,^ab Nikita V. Minaev,^c Anastasia Frolova,^a Svetlana Kotova,

^ad Nadezhda Aksenova,^ad Zahra Heydari,^e Elena Semenova,^f Tatyana Khlebnikova,^ag Elena N. Golubeva,^h Sergei Kostjuk,^aij Massoud Vosough,^e Peter S. Timashev

^abcdh and Anastasia I. Shpichka

*^ab

Author affiliations

* Corresponding authors

^a Institute for Regenerative Medicine, Sechenov University, Moscow, Russia
E-mail: ana-shpichka@yandex.ru

^b World-Class Research Center "Digital biodesign and personalized healthcare", Sechenov University, Moscow, Russia

^c Institute of Photon Technologies, Research Center Crystallography and Photonics RAS, Moscow, Russia

^d Department of Polymers and Composites, N.N.Semenov Institute of Chemical Physics, Moscow, Russia

^e Department of Regenerative Medicine, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

^f Institute for City Development, Sevastopol State University, Sevastopol, Russia

^g Institute for Uronephrology and Reproductive Health, Sechenov University, Moscow, Russia

^h Chemistry Department, Lomonosov Moscow State University, Moscow, Russia

ⁱ Research Institute for Physical Chemical Problems of the Belarusian State University, Minsk, Belarus

^j Department of Chemistry, Belarusian State University, Minsk, Belarus

Abstract

The development of thermolabile substance carriers with a variable shape, size, and release kinetics is one of the most difficult goals of the pharmaceutical industry. Here, we propose to use the two-step combination of two-photon polymerization (2PP) and micromolding techniques to fabricate particles of a preset shape and size from star-shaped methacrylate functionalized poly(D,L)-lactides. Using a 2PP set-up, we fabricated an E-Shell cube-patterned matrix used to prepare a silicon mold. Then this mold was filled with functionalized poly(D,L)-lactides mixed with 4,4′-bis(dimethylamino)benzophenone as a photoinitiator and exposed to UV irradiation to crosslink particles which were further easily detached. The study revealed that the arm length of the functionalized polylactides caused differences in the mechanical properties and surface topography of the fabricated particles that determined their degradation rate, drug loading and release. Using the arm length as a structure parameter, one can prepare tailored polylactide particles with controllable substance release.

Molecular Systems Design & Engineering

Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides

Abstract

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Approach to tune drug release in particles fabricated from methacrylate functionalized polylactides

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