Issue 8, 2021, Issue in Progress
From the journal:

RSC Advances

Tailored nanotopography of photocurable composites for control of cell migration†

Sebastian Hasselmann, ORCID logo a   Caroline Kopittke, ORCID logo ‡a   Maria Götz,a   Patrick Witzel,a   Jacqueline Riffel§a  and  Doris Heinrich ORCID logo *ab  

* Corresponding authors

a Fraunhofer Institute for Silicate Research ISC, Neunerplatz 2, 97082 Würzburg, Germany
E-mail: doris.heinrich@isc.fraunhofer.de

b Leiden University, Huygens-Kamerlingh Onnes Laboratory, Niels Bohrweg 2, 2333 CA Leiden, The Netherlands

Abstract

External mechanical stimuli represent elementary signals for living cells to adapt to their adjacent environment. These signals range from bulk material properties down to nanoscopic surface topography and trigger cell behaviour. Here, we present a novel approach to generate tailored surface roughnesses in the nanometer range to tune surface properties by particle size and volume ratio. Time-resolved local mean-squared displacement (LMSD) analysis of amoeboid cell migration reveals that nanorough surfaces alter effectively cell migration velocities and the active cell migration phases. Since the UV curable composite material is easy to fabricate and can be structured via different light based processes, it is possible to generate hierarchical 3D cell scaffolds for tissue engineering or lab-on-a-chip applications with adjustable surface roughness in the nanometre range.

Graphical abstract: Tailored nanotopography of photocurable composites for control of cell migration

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D0RA06530G
Article type
Paper
Submitted
28 Jul 2020
Accepted
31 Oct 2020
First published
21 Jan 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 4286-4296

Permissions

Request permissions

Tailored nanotopography of photocurable composites for control of cell migration

S. Hasselmann, C. Kopittke, M. Götz, P. Witzel, J. Riffel and D. Heinrich, RSC Adv., 2021, 11, 4286 DOI: 10.1039/D0RA06530G

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements