Issue 9, 2021

Mechanochemical reactivity inhibited, prohibited and reversed by liquid additives: examples from crystal-form screens

Abstract

We demonstrate that liquid additives can exert inhibitive or prohibitive effects on the mechanochemical formation of multi-component molecular crystals, and report that certain additives unexpectedly prompt the dismantling of such solids into physical mixtures of their constituents. Computational methods were employed in an attempt to identify possible reasons for these previously unrecognised effects of liquid additives on mechanochemical transformations.

Graphical abstract: Mechanochemical reactivity inhibited, prohibited and reversed by liquid additives: examples from crystal-form screens

Supplementary files

Article information

Article type
Edge Article
Submitted
12 Sep 2020
Accepted
28 Dec 2020
First published
20 Jan 2021
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2021,12, 3264-3269

Mechanochemical reactivity inhibited, prohibited and reversed by liquid additives: examples from crystal-form screens

M. Arhangelskis, D. Bučar, S. Bordignon, M. R. Chierotti, S. A. Stratford, D. Voinovich, W. Jones and D. Hasa, Chem. Sci., 2021, 12, 3264 DOI: 10.1039/D0SC05071G

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