Issue 4, 2021
From the journal:

Nanoscale Advances

A review on the cytotoxicity of graphene quantum dots: from experiment to simulation

Lijun Liang, ORCID logo a   Xiangming Peng,b   Fangfang Sun,a   Zhe Kong*c  and  Jia-Wei Shen ORCID logo *d  

* Corresponding authors

a College of Automation, Hangzhou Dianzi University, Hangzhou, People's Republic of China
E-mail: zhekong@hdu.edu.cn
Fax: +86 571 87951895

b Department of Clinical Laboratory, GuangZhou Red Cross Hospital, 396 Tongfu Zhong Road, Guangzhou 510220, GuangDong, China

c Center of Advanced Optoelectronic Materials and Devices, College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou, People's Republic of China

d School of Medicine, Hangzhou Normal University, Hangzhou, People's Republic of China
E-mail: shen.jiawei@hotmail.com

Abstract

Graphene quantum dots (GQDs) generate intrinsic fluorescence and improve the aqueous stability of graphene oxide (GO) while maintaining wide chemical adaptability and high adsorption capacity. Despite GO's remarkable advantages in bio-imaging, bio-sensing, and other biomedical applications, many experiments and simulations have focused on the biosafety of GQDs. Here, we review the findings on the biosafety of GQDs from experiments; then, we review the results from simulated interactions with biological membranes, DNA molecules, and proteins; finally, we examine the intersection between experiments and simulations. The biosafety results from simulations are explained in detail. Based on the literature and our experiments, we also discuss the trends toward GQDs with better biosafety.

Graphical abstract: A review on the cytotoxicity of graphene quantum dots: from experiment to simulation

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/D0NA00904K
Article type
Review Article
Submitted
28 Oct 2020
Accepted
25 Dec 2020
First published
26 Dec 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2021,3, 904-917

Permissions

Request permissions

A review on the cytotoxicity of graphene quantum dots: from experiment to simulation

L. Liang, X. Peng, F. Sun, Z. Kong and J. Shen, Nanoscale Adv., 2021, 3, 904 DOI: 10.1039/D0NA00904K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements