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Highly Sensitive Fluorescent Probe for Detection of Paraquat Based on Nanocrystals

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Abstract

Paraquat is one of the most toxic materials widely applied in agriculture in most countries. In the present study, a simple, innovative and inexpensive nano biosensor which is based on a thioglycolic acid (TGA) - CdTe@CdS core-shell nanocrystals (NCs) to detect paraquat, is suggested. The NCs based biosensor shows a linear working range of 10–100 nM, and limited detection of 3.5 nM. The proposed sensor that has been well used for the detection and determination of paraquat in natural water samples is collected from corn field and a canal located near to the corn field yielding recoveries as high as 98%. According to our findings, the developed biosensor shows reproducibility and high sensitivity to determine paraquat in natural water samples in which the amount of paraquat has low levels. The suggested method is efficiently applied to paraquat determination in the samples of natural water that are collected from a tap water and a canal located near to the cornfield.

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References

  1. Siangproh W, Somboonsuk T, Chailapakul O, Songsrirote K (2017) Novel colorimetric assay for paraquat detection on-silica bead using negatively charged silver nanoparticles. Talanta 174:448–453. https://doi.org/10.1016/j.talanta.2017.06.045

    Article  CAS  PubMed  Google Scholar 

  2. dos Santos LBO, Infante CMC, Masini JC (2010) Development of a sequential injection–square wave voltammetry method for determination of paraquat in water samples employing the hanging mercury drop electrode. Anal Bioanal Chem 396:1897–1903. https://doi.org/10.1007/s00216-009-3429-x

    Article  CAS  PubMed  Google Scholar 

  3. Chuntib P, Themsirimongkon S, Saipanya S, Jakmunee J (2017) Sequential injection differential pulse voltammetric method based on screen printed carbon electrode modified with carbon nanotube/Nafion for sensitive determination of paraquat. Talanta 170:1–8. https://doi.org/10.1016/j.talanta.2017.03.073

    Article  CAS  PubMed  Google Scholar 

  4. Gao R, Choi N, Chang S-I et al (2010) Highly sensitive trace analysis of paraquat using a surface-enhanced Raman scattering microdroplet sensor. Anal Chim Acta 681:87–91. https://doi.org/10.1016/j.aca.2010.09.036

    Article  CAS  PubMed  Google Scholar 

  5. Sun S, Li F, Liu F et al (2015) Fluorescence detecting of paraquat using host-guest chemistry with cucurbit[8]uril. Sci Rep 4:3570. https://doi.org/10.1038/srep03570

    Article  Google Scholar 

  6. de Figueiredo-Filho LCS, Baccarin M, Janegitz BC, Fatibello-Filho O (2017) A disposable and inexpensive bismuth film minisensor for a voltammetric determination of diquat and paraquat pesticides in natural water samples. Sensors Actuators B Chem 240:749–756. https://doi.org/10.1016/j.snb.2016.08.157

    Article  CAS  Google Scholar 

  7. Onyon LJ, Volans GN (1987) The epidemiology and prevention of paraquat poisoning. Hum Toxicol 6:19–29. https://doi.org/10.1177/096032718700600104

    Article  CAS  PubMed  Google Scholar 

  8. Tu J, Xiao L, Jiang Y et al (2015) Near-infrared fluorescent turn-on detection of paraquat using an assembly of squaraine and surfactants. Sensors Actuators B Chem 215:382–387. https://doi.org/10.1016/j.snb.2015.04.015

    Article  CAS  Google Scholar 

  9. Geng P, Jinzhang C, Lijing Z, Mengzhi X, Zezheng L, Jing Z, Zhiyi W, Xianqin Wang CW, Ma J (2017) Liver tissue metabonomics in rat after acute paraquat poisoning gas chromatography-mass spectrometry. Int J Clin Exp Med 10:937–943

    CAS  Google Scholar 

  10. Faust SD, Hunter NE (1965) Chemical methods for the detection of aquatic herbicides. J Am Water Works Assoc 57:1028–1037. https://doi.org/10.1002/j.1551-8833.1965.tb01494.x

    Article  CAS  Google Scholar 

  11. Gill R, Qua SC, Moffat AC (1983) High-performance liquid chromatography of paraquat and diquat in urine with rapid sample preparation involving ion-pair extraction on disposable cartridges of octadecyl-silica. J Chromatogr A 255:483–490. https://doi.org/10.1016/S0021-9673(01)88303-5

    Article  CAS  Google Scholar 

  12. Tomková H, Sokolová R, Opletal T et al (2018) Electrochemical sensor based on phospholipid modified glassy carbon electrode - determination of paraquat. J Electroanal Chem 821:33–39. https://doi.org/10.1016/j.jelechem.2017.12.048

    Article  CAS  Google Scholar 

  13. Jain A, Verma KK, Townshend A (1993) Determination of paraquat by flow-injection spectrophotometry. Anal Chim Acta 284:275–279. https://doi.org/10.1016/0003-2670(93)85311-7

    Article  CAS  Google Scholar 

  14. Zhao Z, Zhang F, Zhang Z (2018) A facile fluorescent “turn-off” method for sensing paraquat based on pyranine-paraquat interaction. Spectrochim Acta Part A Mol Biomol Spectrosc 199:96–101. https://doi.org/10.1016/j.saa.2018.03.042

    Article  CAS  Google Scholar 

  15. Wigfield YY, McCormack KA, Grant R (1993) Simultaneous determination of residues of paraquat and diquat in potatoes using high-performance capillary electrophoresis with a ultraviolet detection. J Agric Food Chem 41:2315–2318. https://doi.org/10.1021/jf00036a018

    Article  CAS  Google Scholar 

  16. Núñez O, Moyano E, Galceran M (2002) Solid-phase extraction and sample stacking–capillary electrophoresis for the determination of quaternary ammonium herbicides in drinking water. J Chromatogr A 946:275–282. https://doi.org/10.1016/S0021-9673(01)01562-X

    Article  PubMed  Google Scholar 

  17. Ensafi AA, Kazemifard N, Rezaei B (2015) A simple and rapid label-free fluorimetric biosensor for protamine detection based on glutathione-capped CdTe quantum dots aggregation. Biosens Bioelectron 71:243–248. https://doi.org/10.1016/j.bios.2015.04.015

    Article  CAS  PubMed  Google Scholar 

  18. Ding L, Ruan Y, Li T et al (2018) Nitric oxide optical fiber sensor based on exposed core fibers and CdTe/CdS quantum dots. Sensors Actuators B Chem 273:9–17. https://doi.org/10.1016/j.snb.2018.06.012

    Article  CAS  Google Scholar 

  19. Dong L-Y, Wang L-Y, Wang X-F et al (2016) Development of fluorescent FRET probe for determination of glucose based on β-cyclodextrin modified ZnS-quantum dots and natural pigment 3-hydroxyflavone. Dye Pigment 128:170–178. https://doi.org/10.1016/j.dyepig.2016.01.032

    Article  CAS  Google Scholar 

  20. Ding L, Zhang B, Xu C et al (2016) Fluorescent glucose sensing using CdTe/CdS quantum dots–glucose oxidase complex. Anal Methods 8:2967–2970. https://doi.org/10.1039/C5AY03205A

    Article  CAS  Google Scholar 

  21. Algar WR, Krull UJ (2008) Quantum dots as donors in fluorescence resonance energy transfer for the bioanalysis of nucleic acids, proteins, and other biological molecules. Anal Bioanal Chem 391:1609–1618. https://doi.org/10.1007/s00216-007-1703-3

    Article  CAS  PubMed  Google Scholar 

  22. Zhang M, Cao X, Li H et al (2012) Sensitive fluorescent detection of melamine in raw milk based on the inner filter effect of Au nanoparticles on the fluorescence of CdTe quantum dots. Food Chem 135:1894–1900. https://doi.org/10.1016/j.foodchem.2012.06.070

    Article  CAS  PubMed  Google Scholar 

  23. Shen S-L, Zhang X-F, Ge Y-Q et al (2018) A novel ratiometric fluorescent probe for the detection of HOCl based on FRET strategy. Sensors Actuators B Chem 254:736–741. https://doi.org/10.1016/j.snb.2017.07.158

    Article  CAS  Google Scholar 

  24. Frigerio C, Ribeiro DSM, Rodrigues SSM et al (2012) Application of quantum dots as analytical tools in automated chemical analysis: A review. Anal Chim Acta 735:9–22. https://doi.org/10.1016/j.aca.2012.04.042

    Article  CAS  PubMed  Google Scholar 

  25. Bagheri Z, Ehtesabi H, Hallaji Z et al (2018) Investigation the cytotoxicity and photo-induced toxicity of carbon dot on yeast cell. Ecotoxicol Environ Saf 161:245–250. https://doi.org/10.1016/j.ecoenv.2018.05.071

    Article  CAS  PubMed  Google Scholar 

  26. Foubert A, Beloglazova NV, Rajkovic A et al (2016) Bioconjugation of quantum dots: Review & impact on future application. TrAC Trends Anal Chem 83:31–48. https://doi.org/10.1016/j.trac.2016.07.008

    Article  CAS  Google Scholar 

  27. Elmizadeh H, Soleimani M, Faridbod F, Bardajee GR (2018) Fabrication and optimization of a sensitive tetracycline fluorescent nano-sensor based on oxidized starch polysaccharide biopolymer-capped CdTe/ZnS quantum dots: Box–Behnken design. J Photochem Photobiol A Chem 367:188–199. https://doi.org/10.1016/j.jphotochem.2018.08.021

    Article  CAS  Google Scholar 

  28. Karakoti AS, Shukla R, Shanker R, Singh S (2015) Surface functionalization of quantum dots for biological applications. Adv Colloid Interface Sci 215:28–45. https://doi.org/10.1016/j.cis.2014.11.004

    Article  CAS  PubMed  Google Scholar 

  29. Banerjee A, Grazon C, Nadal B et al (2015) Fast, efficient, and stable conjugation of multiple DNA strands on colloidal quantum dots. Bioconjug Chem 26:1582–1589. https://doi.org/10.1021/acs.bioconjchem.5b00221

    Article  CAS  PubMed  Google Scholar 

  30. Banerjee A, Grazon C, Pons T et al (2017) A novel type of quantum dot–transferrin conjugate using DNA hybridization mimics intracellular recycling of endogenous transferrin. Nanoscale 9:15453–15460. https://doi.org/10.1039/C7NR05838A

    Article  CAS  PubMed  Google Scholar 

  31. Wang J, Jiang P, Gao L et al (2013) Unique self-assembly properties of a bridge-shaped protein dimer with quantum dots. J Nanoparticle Res 15:1914. https://doi.org/10.1007/s11051-013-1914-9

    Article  Google Scholar 

  32. Su X, Chan C, Shi J et al (2017) A graphene quantum dot@Fe 3 O 4 @SiO 2 based nanoprobe for drug delivery sensing and dual-modal fluorescence and MRI imaging in cancer cells. Biosens Bioelectron 92:489–495. https://doi.org/10.1016/j.bios.2016.10.076

    Article  CAS  PubMed  Google Scholar 

  33. Jin T, Sun D, Su JY et al (2009) Antimicrobial efficacy of zinc oxide quantum dots against Listeria monocytogenes, Salmonella Enteritidis, and Escherichia coli O157:H7. J Food Sci 74:M46–M52. https://doi.org/10.1111/j.1750-3841.2008.01013.x

    Article  CAS  PubMed  Google Scholar 

  34. Zhou J, Deng W, Wang Y et al (2016) Cationic carbon quantum dots derived from alginate for gene delivery: One-step synthesis and cellular uptake. Acta Biomater 42:209–219. https://doi.org/10.1016/j.actbio.2016.06.021

    Article  CAS  PubMed  Google Scholar 

  35. Samia ACS, Chen X, Burda C (2003) Semiconductor quantum dots for photodynamic therapy. J Am Chem Soc 125:15736–15737. https://doi.org/10.1021/ja0386905

    Article  CAS  PubMed  Google Scholar 

  36. Feizi S, Zare H, Hoseinpour M (2018) Investigation of dosimetric characteristics of a core–shell quantum dots nano composite (CdTe/CdS/PMMA): fabrication of a new gamma sensor. Appl Phys A 124:420. https://doi.org/10.1007/s00339-018-1837-5

    Article  CAS  Google Scholar 

  37. Zare H, Ghalkhani M, Akhavan O et al (2017) Highly sensitive selective sensing of nickel ions using repeatable fluorescence quenching-emerging of the CdTe quantum dots. Mater Res Bull 95:532–538. https://doi.org/10.1016/j.materresbull.2017.08.015

    Article  CAS  Google Scholar 

  38. Li Y, Sun L, Liu Q et al (2016) Photoelectrochemical CaMV35S biosensor for discriminating transgenic from non-transgenic soybean based on SiO2@CdTe quantum dots core-shell nanoparticles as signal indicators. Talanta 161:211–218. https://doi.org/10.1016/j.talanta.2016.08.047

    Article  CAS  PubMed  Google Scholar 

  39. İnal EK (2020) A fluorescent chemosensor based on schiff base for the determination of Zn2+, Cd2 + and Hg2+. J Fluoresc 30:891–900. https://doi.org/10.1007/s10895-020-02563-6

    Article  CAS  PubMed  Google Scholar 

  40. Nirmal M, Dabbousi BO, Bawendi MG et al (1996) Fluorescence intermittency in single cadmium selenide nanocrystals. Nature 383:802–804. https://doi.org/10.1038/383802a0

    Article  CAS  Google Scholar 

  41. Marandi M, Emrani B, Zare H (2017) Synthesis of highly luminescent CdTe/CdS core-shell nanocrystals by optimization of the core and shell growth parameters. Opt Mater (Amst) 69:358–366. https://doi.org/10.1016/j.optmat.2017.04.058

    Article  CAS  Google Scholar 

  42. Yu Y, Zhang K, Li Z, Sun S (2012) Synthesis and luminescence characteristics of DHLA-capped PbSe quantum dots with biocompatibility. Opt Mater (Amst) 34:793–798. https://doi.org/10.1016/j.optmat.2011.11.008

    Article  CAS  Google Scholar 

  43. Wu T, He K, Zhan Q et al (2015) Partial protection of N-acetylcysteine against MPA-capped CdTe quantum dot-induced neurotoxicity in rat primary cultured hippocampal neurons. Toxicol Res (Camb) 4:1613–1622. https://doi.org/10.1039/C5TX00127G

    Article  CAS  Google Scholar 

  44. Chen Y, Chen Z, He Y et al (2010) L-cysteine-capped CdTe QD-based sensor for simple and selective detection of trinitrotoluene. Nanotechnology 21:125502. https://doi.org/10.1088/0957-4484/21/12/125502

    Article  CAS  PubMed  Google Scholar 

  45. Shankara Narayanan S, Sinha SS, Verma PK, Pal SK (2008) Ultrafast energy transfer from 3-mercaptopropionic acid-capped CdSe/ZnS QDs to dye-labelled DNA. Chem Phys Lett 463:160–165. https://doi.org/10.1016/j.cplett.2008.08.057

    Article  CAS  Google Scholar 

  46. Jhonsi MA, Renganathan R (2010) Investigations on the photoinduced interaction of water soluble thioglycolic acid (TGA) capped CdTe quantum dots with certain porphyrins. J Colloid Interface Sci 344:596–602. https://doi.org/10.1016/j.jcis.2010.01.022

    Article  CAS  PubMed  Google Scholar 

  47. Khan S, Carneiro LSA, Vianna MS et al (2017) Determination of histamine in tuna fish by photoluminescence sensing using thioglycolic acid modified CdTe quantum dots and cationic solid phase extraction. J Lumin 182:71–78. https://doi.org/10.1016/j.jlumin.2016.09.041

    Article  CAS  Google Scholar 

  48. Fernández-Argüelles MT, Costa-Fernández JM, Pereiro R, Sanz-Medel A (2008) Simple bio-conjugation of polymer-coated quantum dots with antibodies for fluorescence-based immunoassays. Analyst 133:444. https://doi.org/10.1039/b802360n

    Article  CAS  PubMed  Google Scholar 

  49. Shiohara A, Hanada S, Prabakar S et al (2010) Chemical reactions on surface molecules attached to silicon quantum dots. J Am Chem Soc 132:248–253. https://doi.org/10.1021/ja906501v

    Article  CAS  PubMed  Google Scholar 

  50. Pourghobadi Z, Mirahmadpour P, Zare H (2018) Fluorescent biosensor for the selective determination of dopamine by TGA-capped CdTe quantum dots in human plasma samples. Opt Mater (Amst) 84:757–762. https://doi.org/10.1016/j.optmat.2018.08.003

    Article  CAS  Google Scholar 

  51. Uvarov V, Popov I (2007) Metrological characterization of X-ray diffraction methods for determination of crystallite size in nano-scale materials. Mater Charact 58:883–891. https://doi.org/10.1016/j.matchar.2006.09.002

    Article  CAS  Google Scholar 

  52. Lakowicz JR (2013) Principles of fluorescence spectroscopy. Springer Sci Bus Media, Berlin

  53. Matylitsky VV, Dworak L, Breus VV et al (2009) Ultrafast charge separation in multiexcited CdSe quantum dots mediated by adsorbed electron acceptors. J Am Chem Soc 131:2424–2425. https://doi.org/10.1021/ja808084y

    Article  CAS  PubMed  Google Scholar 

  54. Li H, Liu J, Yang X (2015) Facile synthesis of glutathione-capped CdS quantum dots as a fluorescence sensor for rapid detection and quantification of paraquat. Anal Sci 31:1011–1017. https://doi.org/10.2116/analsci.31.1011

    Article  CAS  PubMed  Google Scholar 

  55. Jenkins R, de Vries JL (1997) An introduction to X-ray powder diffractometryNo Title. NV Philips 36:1128

    Google Scholar 

  56. Scherrer PJNGWG (1918) Estimation of the size and internal structure of colloidal particles by means of röntgen. Nachr Ges Wiss Göttingen 2:96–100

    Google Scholar 

  57. Ghalkhani M, Maghsoudi S, Saeedi R, Khaloo SS (2019) Ultrasensitive quantification of paraquat using a newly developed sensor based on silver nanoparticle-decorated carbon nanotubes. J Iran Chem Soc 16:1301–1309. https://doi.org/10.1007/s13738-019-01605-6

    Article  CAS  Google Scholar 

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Acknowledgements

The authors greatly appreciate the financial support to the present study by the Khorramabad Branch of Islamic Azad University, Lorestan Province, Iran.

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Authors and Affiliations

  1. Department of Chemistry, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran

    Zeinab Pourghobadi & Hadis Makanali

  2. Physics Department, Faculty of Science, Yazd University, P.Box 89195_714, Yazd, Iran

    Hakimeh Zare

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  1. Zeinab Pourghobadi
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Pourghobadi, Z., Makanali, H. & Zare, H. Highly Sensitive Fluorescent Probe for Detection of Paraquat Based on Nanocrystals. J Fluoresc 31, 559–567 (2021). https://doi.org/10.1007/s10895-020-02679-9

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