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Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica

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Abstract

An efficient and facile method has been developed for the synthesis of various 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino-N-(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as an efficient catalyst in ethanol under reflux. High yield of the desired products, reusability of the catalyst, and effortless workup step without using chromatography are the advantages of this method.

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Acknowledgements

The authors are thankful to Islamic Azad University, Ahwaz Branch for the partial support to carry out this work.

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Authors and Affiliations

  1. Department of Chemistry, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran

    Ayeh Rayatzadeh & Sirous Haghipour

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  1. Ayeh Rayatzadeh
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  2. Sirous Haghipour
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Correspondence to Ayeh Rayatzadeh.

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Rayatzadeh, A., Haghipour, S. Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica. Monatsh Chem 152, 103–107 (2021). https://doi.org/10.1007/s00706-020-02720-4

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  • DOI: https://doi.org/10.1007/s00706-020-02720-4

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