Abstract
In this paper we formulate a multi-scale nested immuno-epidemiological model of HIV on complex networks. The system is described by ordinary differential equations coupled with a partial differential equation. First, we prove the existence and uniqueness of the immunological model and then establish the well-posedness of the multi-scale model. We derive an explicit expression of the basic reproduction number \({\mathscr {R}}_{0}\) of the immuno-epidemiological model. The system has a disease-free equilibrium and an endemic equilibrium. The disease-free equilibrium is globally stable when \({\mathscr {R}}_{0}<1\) and unstable when \({\mathscr {R}}_0 >1\). Numerical simulations suggest that \({\mathscr {R}}_{0}\) increases as the number of nodes in the network increases. Further, we find that for a scale-free network the number of infected individuals at equilibrium is a hump-like function of the within-host reproduction number; however, the dependence becomes monotone if the network has predominantly low connectivity nodes or high connectivity nodes.
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Maia Martcheva was partially supported by NSF DMS-1951595. Necibe Tuncer was partially supported by NSF DMS-1951626.
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Gupta, C., Tuncer, N. & Martcheva, M. A Network Immuno-Epidemiological HIV Model. Bull Math Biol 83, 18 (2021). https://doi.org/10.1007/s11538-020-00855-3
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DOI: https://doi.org/10.1007/s11538-020-00855-3