A new biological implant, extracellular matrix of bovine peritoneum, was developed and obtained for plastic surgery of the anterior abdominal wall defects. The material was implanted to rats into the anterior abdominal wall. The content of rejection markers (TNF, IL-2, C-reactive protein) and the morphological picture of the implantation zone at the early stages (30 days) after surgery were evaluated. The studied material at this stage demonstrated adequate biocompatibility; the formation of mature, consistent contact with the tissues of the anterior abdominal wall and minimum tissue inflammatory reactions were observed.
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Badyrov RM, Abatov NT, Tussupbekova MM, Alberton JN, Mussabekov IK. Results after application of the extracellular bovine-derived peritoneum matrix for abdominal wall reconstruction in the long-term experiment. Nauka Zrdavookhaneniya. 2018;(1):24-35. Russian.
Efimov DY, Karytka AA, Yanushevskaya EA, Berezneva YS, Zhuk HV, Korotkov SV, Dzyadzko AM, Shcherba AE, Rummo OO. Soluble cytokine profiles and complications after liver transplantation. Voenn. Med. 2016;(1):75-80. Russian.
Abatov NT, Abugaliev KR, Badyrov RM, Ogai VB, Abatova AN, Asamidanov EM. Patent of Kazakhstan Republic No. 33801. A method of fabrication of extracellular matrix of xenoperitoneum for the plasty of anterior abdominal wall hernias. Published July 26, 2019.
Abdelfatah MM, Rostambeigi N, Podgaetz E, Sarr MG. Longterm outcomes (>5-year follow-up) with porcine acellular dermal matrix (Permacol) in incisional hernias at risk for infection. Hernia. 2015;19(1):135-140.
Armellino MF, De Stefano G, Scardi F, Forner AL, Ambrosino F, Bellotti R, Robustelli U, De Stefano G. Use of Permacol in complicated incisional hernia. Chir. Ital. 2006;58(5):627-630.
Brown BN, Badylak SF. Extracellular matrix as an inductive scaffold for functional tissue reconstruction. Transl. Res. 2014;163(4):268-285.
López-Cano M, Armengol-Carrasco M. Biological scaffolds in reparative surgery for abdominal wall hernias. Am. J. Surg. 2012;203(4):555. doi: https://doi.org/10.1016/j.amjsurg.2009.09.005
Greenhalgh DG, Sprugel KH, Murray MJ, Ross R. PDGF and FGF stimulate healing in the genetically diabetic mouse. Am. J. Pathol. 1990;136(6):1235-1246.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 9, pp. 361-365, September, 2020
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Maxyatkina, L.V., Badyrov, R.M., Abatov, N.T. et al. Experimental Extracellular Matrix of the Xenoperitoneum: Comprehensive Assessment of a New Biological Material for Plastic Surgery of Anterior Abdominal Wall Defects. Bull Exp Biol Med 170, 364–367 (2021). https://doi.org/10.1007/s10517-021-05068-9
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DOI: https://doi.org/10.1007/s10517-021-05068-9